原发性乳腺癌患者恶性钙化钼靶征象与CD31、E-Cad表达的关系分析  

Analysis of the relationship between the signs of malignant calcification mammography and the expressions of CD31 and E-Cad in patients with primary breast cancer

作　　者：吴东旭 金诚 金燕燕 WU Dongxu;JIN Cheng;JIN Yanyan(Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]东阳市人民医院放射科

出　　处：《全科医学临床与教育》2022年第6期528-533,共6页Clinical Education of General Practice

摘　　要：目的探讨原发性乳腺癌患者恶性钙化钼靶征象与血小板内皮细胞黏附分子(CD31)、上皮钙黏蛋白(ECad)表达的关系。方法回顾性收集309例原发性乳腺癌患者,根据CD31及E-Cad的阳性、阴性按四象限法分为四组,A组为CD31阳性E-Cad阳性共53例,B组为CD31阴性E-Cad阳性共105例,C组为CD31阳性E-Cad阴性共48例,D组为CD31阴性E-Cad阴性共103例。所有患者均接受钼靶X线检查和CD31及E-Cad检测。统计四组恶性钙化发生率,分析钼靶X线形态及数目征象与CD31及E-Cad表达的相关性。结果309例原发性乳腺癌患者中,恶性钙化者104例,发生率为33.66%。其中A组25例,B组42例,C组22例,D组15例,发生率分别为47.17%、40.00%、45.83%和14.56%。A组、B组和C组与D组比较,差异有统计意义(χ^(2)分别=10.81、9.75、9.73,P均<0.05)。CD31阳性及E-Cad阴性患者点状及多形态恶性钙化比例均明显高于CD31阴性及E-Cad阳性患者,差异有统计意义(χ^(2)分别=84.63、66.64、56.77、37.37,P均<0.05)。CD31阳性及E-Cad阴性患者恶性钙化灶数目<15个、15~35个、>35个的例数均明显多于CD31阴性及E-Cad阳性患者,差异有统计意义(χ^(2)分别=28.82、83.68、47.71、21.52、52.86、22.44,P均<0.05)。结论恶性钙化钼靶征象与CD31阳性表达和E-Cad阴性表达的存在较强相关性,CD31、E-Cad表达可为原发性乳腺癌恶性钙化钼靶X线检查提供分子生物学支撑,对临床治疗方案选择及预后评估有重要意义。Objective To investigate the relationship between the signs of malignant calcification mammography and the expressions of CD31 and E-Cad in patients with primary breast cancer.Methods A total of 309 patients with primary breast cancer were retrospectively collected and divided into four groups according to CD31 and E-Cad four-quadrant method.53 cases with positive CD31 and positive E-Cad were enrolled in group A,105 cases were negative CD31 and positive E-Cad were enrolled in group B,48 cases with positive CD31 and negative E-Cad were enrolled,in group C,and 103 cases with negative CD31 and negative E-Cad were enrolled in group D.All patients received mammography and detection of CD31 and E-Cad.The incidence of malignant calcification in the four groups was counted,and the correlation between the X-ray morphology and number of mammography and the expressions of CD31 and E-Cad was analyzed.Results Among the 309 patients with primary breast cancer,104 had malignant calcification,the incidence rate was 33.66%.Among them,there were 25 cases in group A,42 cases in group B,22 cases in group C,and 15 cases in group D,the incidence rates were 47.17%,40.00%,45.83%and 14.56%,respectively.Compared with group D,the incidence rate of malignant calcification of group A,group B and group C was higher(χ^(2)=10.81,9.75,9.73,P<0.05).The proportions of punctate and polymorphic malignant calcifications in positive CD31 and negative E-Cad patients were significantly higher than those in negative CD31 and positive E-Cad patients(χ^(2)=84.63,66.64,56.77,37.37,P<0.05).The number of malignant calcifications that<15,15~35,>35 in positive CD31 and negative E-Cad patients was significantly more than that in negative CD31 and positive ECad patients,and the differences were statistically significant(χ^(2)=28.82,83.68,47.71,21.52,52.86,22.44,P<0.05).Conclusion There is a strong correlation between the signs of malignant calcification mammography and the positive expression of CD31 and the negative expression of E-Cad.The expressions of CD31

关 键 词：原发性乳腺癌 恶性钙化 钼靶X线 血小板内皮细胞黏附分子 上皮钙黏蛋白 

分 类 号：R737.9[医药卫生—肿瘤]