吡拉西坦联合尼莫地平治疗脑梗塞后血管性痴呆的效果及对患者血管内皮功能及GQOL-74评分的影响  

Effect of piracetam combined with nimodipine on vascular dementia after cerebral infarction and its influences on vascular endothelial function and GQOL-74 score of patients

作　　者：张建霞 郝应娥 ZHANG Jianxia;HAO Ying'e(Yulin Hospital of Traditional Chinese Medicine,Yulin 719000,China)

机构地区：[1]榆林市中医医院,陕西榆林719000

出　　处：《临床医学研究与实践》2022年第18期24-27,共4页Clinical Research and Practice

摘　　要：目的探讨吡拉西坦联合尼莫地平治疗脑梗塞后血管性痴呆的效果及对患者血管内皮功能及生活质量综合评定量表-74(GQOL-74)评分的影响。方法选取2018年11月至2020年9月我院神经内科收治的70例脑梗塞后血管性痴呆患者为本次研究对象,将其按照随机数字表法分为对照组与观察组,各35例。对照组采用尼莫地平治疗,观察组在尼莫地平的基础上加用吡拉西坦治疗。比较两组的治疗效果。结果观察组的治疗总有效率为97.14%,高于对照组的82.86%(P<0.05)。治疗后,两组的蒙特利尔认知评估量表(MoCA)及日常生活活动能力(ADL)评分均升高,神经精神症状问卷(NPI)评分均降低,且观察组优于对照组(P<0.05)。治疗后,两组的一氧化氮(NO)水平均升高,内皮素-1(ET-1)水平均降低,且观察组优于对照组(P<0.05)。治疗后,两组的全血黏度高切、全血黏度低切、血浆黏度及红细胞聚集指数均明显降低,且观察组低于对照组(P<0.05)。两组的药物不良反应总发生率无明显差异(P>0.05)。治疗后,两组GQOL-74各项评分均升高,且观察组高于对照组(P<0.05)。结论吡拉西坦联合尼莫地平治疗脑梗塞后血管性痴呆的效果显著,可改善患者的认知功能、神经精神状态及日常生活能力,提高血管内皮功能及生活质量水平,降低血黏度,值得临床推广与应用。Objective To investigate the effect of piracetam combined with nimodipine on vascular dementia after cerebral infarction and its influences on vascular endothelial function and generic quality of life inventory-74(GQOL-74)score of patients.Methods A total of 70 patients with vascular dementia after cerebral infarction admitted in the neurology department of our hospital from November 2018 to September 2020 were selected as the research objects,and the patients were divided into control group and observation group according to random number table method,with 35 cases in each group.The control group were treated with nimodipine,while the observation group were treated with piracetam on the basis of nimodipine.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment of the observation group was 97.14%,which was higher than 82.86%of the control group(P<0.05).After treatment,Montreal cognitive assessment(MoCA)and activity of daily living(ADL)scores of the two groups increased,neuropsychiatric inventory(NPI)score decreased,and those in the observation group were better than the control group(P<0.05).After treatment,nitric oxide(NO)level increased and endothelin-1(ET-1)level decreased in both groups,and those in the observation group were better than the control group(P<0.05).After treatment,the whole blood viscosity high shear,whole blood viscosity low shear,plasma viscosity and erythrocyte aggregation index of the two groups significantly decreased,and those of the observation group were lower than the control group(P<0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups(P>0.05).After treatment,the scores of GQOL-74 in the two groups increased,and those in the observation group were higher than the control group(P<0.05).Conclusion Piracetam combined with nimodipine is effective in the treatment of vascular dementia after cerebral infarction.It can improve patients'cognitive function,neuropsychiatric state and abili

关 键 词：吡拉西坦 尼莫地平 脑梗塞后血管性痴呆 血管内皮功能 血流流变学 

分 类 号：R743[医药卫生—神经病学与精神病学]