肿瘤微环境在放疗抵抗和复发中的作用及研究进展  

The role and research progress of tumor microenvironment in radiotherapy resistance and recurrence

作　　者：吴杰 石卉[2] 马秋莲 WU Jie;SHI Hui;MA Qiulian.(Department of Medical Imaging, School of Medicine, Jiangsu University, Zhenjiang 212013, China)

机构地区：[1]江苏大学医学院医学影像系,江苏镇江212013 [2]江苏大学附属医院影像科,212001 [3]江苏大学第一临床医学院,212013

出　　处：《临床肿瘤学杂志》2022年第5期467-471,共5页Chinese Clinical Oncology

基　　金：江苏省研究生科研与实践创新计划项目(SJCX19_0577);江苏省大学生创新创业训练计划项目(201910299015Z)。

摘　　要：放射治疗是肿瘤治疗的主要手段之一。目前改善放疗效应的研究多集中在其对肿瘤细胞生物学行为的调控。然而越来越多的研究证实,肿瘤微环境在放疗效应中也发挥着重要的调控作用。本文着重阐述放疗对肿瘤微环境中血管、基质和免疫系统的影响,并讨论其在促进肿瘤放疗抵抗和复发过程中的作用。Radiotherapy is currently one of the main methods of tumor treatment.Presently,most of the researches aimed at improving the responses of radiotherapy just focus on its regulation of the biological behaviors of tumor cells.However,more and more studies have confirmed that the tumor microenvironment(TME)also plays an important regulatory role in the responses of radiotherapy.This review focuses on the effects of radiotherapy on the blood vessels,matrix and immune system in TME,and discusses the role of TME in promoting tumor radiotherapy resistance and recurrence.

关 键 词：放射治疗 肿瘤微环境 缺氧 免疫治疗 

分 类 号：R730[医药卫生—肿瘤]