脂环族溴代阻燃剂的生物富集、代谢及毒性效应研究进展  

Research progress on bioconcentration,metabolism and toxicity of cycloaliphatic brominated flame retardant isomers

作　　者：张贞莹 温蓓[1] 黄红林[1] 张淑贞[1] ZHANG Zhenying;WEN Bei;HUANG Honglin;ZHANG Shuzhen(Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing,100085,China;University of Chinese Academy of Sciences,Beijing,100049,China)

机构地区：[1]中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室,北京100085 [2]中国科学院大学,北京100049

出　　处：《环境化学》2022年第5期1480-1503,共24页Environmental Chemistry

基　　金：国家重点研究发展计划场地土壤专项(2018YFC1801002);国家自然科学基金(41877479,22076213)资助。

摘　　要：以六溴环十二烷(HBCD)为代表的脂环族溴代阻燃剂(CBFRs)被广泛应用于纺织、建材、电子、电气、化工、交通、建材等领域.随着HBCD作为《关于持久性有机污染物的斯德哥尔摩公约》增列持久性有机污染物,与HBCD具有相似结构和性能的四溴环己烷(TBECH)和四溴环辛烷(TBCO)等CBFRs被当作HBCD的潜在替代产品.迄今为止,HBCD、TBECH和TBCO已在大气、水体、土壤等多种环境介质和生物体中被检出,它们在生物体内的代谢转化以及内分泌干扰、神经、生殖、发育等毒性效应亦受到广泛关注.值得指出的是,所有CBFRs均含有同分异构体,表现出异构体选择性的生物富集、代谢和毒性效应.遗憾的是,目前相关研究还十分匮乏.本文从CBFRs的环境暴露水平、生物富集、毒性效应、以及CBFRs的生物转化等方面展开综述,特别强调了从异构体水平研究HBCD及其替代物的必要性.本文有助于全面了解CBFRs生物富集、代谢及毒性效应,对于正确认识和准确评价CBFRs的生态和健康风险具有重要的科学意义.Cycloaliphatic brominated flame retardants(CBFRs),represented by hexabromocyclododecane(HBCD)are widely used in textile,building materials,electronics,electrical,chemical,transportation,building materials and other fields.With the addition of HBCD in the“Stockholm Convention on Persistent Organic Pollutants”as persistent organic pollutants,other types of CBFRs,such as tetrabromocyclohexane(TBECH)and 1,2,5,6-Tetrabromocyclooctane(TBCO),with similar structure and performance to HBCD are regarded as potential substitutes for HBCD.So far,HBCD,TBECH and TBCO have been detected in the atmosphere,water,soil and other environmental media and organisms.Their metabolic transformation in organisms,endocrine interference,nerves,reproduction,development and other toxic effects have been drawn much attention.It should be mentioned that all CBFRs contain isomers,showing isomer-selective bioaccumulation,metabolism,and toxicity.Unfortunately,research at the level of isomers is scarce.In this article,the environmental exposure level,bioconcentration,biotransformation and toxic effects of CBFRs have been reviewed,and the necessity of studying HBCD and its substitutes at the level of isomers has been emphasized.This article helps to fully understand the bioaccumulation,metabolism and toxic effects of CBFRs,which has important scientific significance for the correct understanding and accurate evaluation of the ecological and health risks of CBFRs.

关 键 词：脂环族溴代阻燃剂 异构体 生物富集 毒性效应 生物转化 

分 类 号：X171.5[环境科学与工程—环境科学]