晚期下咽鳞状细胞癌非手术治疗研究进展  

Advances in non-operative treatment of advanced hypopharyngeal squamous cell carcinoma

作　　者：张睿[1] 冯恩梓 任艳鑫[1] 李晓江[1] Zhang Rui;Feng Enzi;Ren Yanxin;Li Xiaojiang(First Department of Head and Neck Surgery,Third Affiliated Hospital of Kunming Medical University(Yunnan Cancer Hospital),Kunming 650118,China)

机构地区：[1]昆明医科大学第三附属医院(云南省肿瘤医院)头颈外一科,昆明650118

出　　处：《国际肿瘤学杂志》2022年第4期233-236,共4页Journal of International Oncology

基　　金：国家自然科学基金(81960489)。

摘　　要：下咽鳞状细胞癌恶性程度较高,发生位置隐匿,早期症状不典型,就诊时患者多已达晚期。手术治疗会使患者失去喉功能,术后生命质量较差。放疗、化疗等非手术治疗的联合应用可提高患者保喉率,并获得与手术治疗相近的生存率。靶向治疗在下咽鳞状细胞癌的治疗中已获得了更好的疗效,免疫治疗在头颈部鳞状细胞癌治疗的应用也取得很大进展,为下咽鳞状细胞癌患者带来新的希望。Hypopharyngeal squamous cell carcinoma has a high degree of malignancy,hidden location,atypical early symptoms,most patients have reached advanced stage at the time of treatment.Surgical treatment will cause patients to lose laryngeal function and poor postoperative quality of life.The combined application of non-operative therapies such as radiotherapy and chemotherapy can improve the larynx preservation rate of patients and obtain a survival rate similar to that of surgical treatment.Targeted therapy has achieved better results in the treatment of hypopharyngeal squamous cell carcinoma,and immunotherapy has also made great progress in the treatment of head and neck squamous cell carcinoma,which brings new hope for patients with hypopharyngeal squamous cell carcinoma.

关 键 词：下咽肿瘤 分子靶向治疗 免疫疗法 综合疗法 非手术治疗 

分 类 号：R739.63[医药卫生—肿瘤]