口服铁剂与炎症性肠病合并缺铁性贫血  

Oral iron supplement and inflammatory bowel disease with iron deficiency anemia

作　　者：鲁苗苗 任越 许灵玲 顾学薇 吕子言 陈栋[4] 金希[5] Lu Miaomiao;Ren Yue;Xu Lingling;Gu Xuewei;Lyu Ziyan;Chen Dong;Jin Xi(Zhejiang University School of Medicine,Hangzhou 310000,China;Department of Gastroenterology,Zhuji People′s Hospital,Shaoxing 311800,China;Wenzhou Medical University,Wenzhou 325035,China;Department of Colorectal Surgery,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;Department of Gastroenterology,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院,杭州310000 [2]诸暨市人民医院消化内科,绍兴311800 [3]温州医科大学,温州325035 [4]浙江大学医学院附属第一医院结直肠外科,杭州310003 [5]浙江大学医学院附属第一医院消化内科,杭州310003

出　　处：《中华炎性肠病杂志（中英文）》2022年第2期150-154,共5页Chinese Journal of Inflammatory Bowel Diseases

摘　　要：缺铁性贫血是炎症性肠病(IBD)常见的并发症之一。口服铁剂是缺铁性贫血常用的治疗手段, 其在IBD患者缺铁性贫血中的应用一直存在争议。IBD患者中存在口服铁剂不耐受以及吸收差等问题。还有研究表明, 口服铁剂会增加IBD患者的疾病活动程度。这可能与肠道铁引起氧化应激从而改变肠道菌群的构成有关。本文综述IBD合并缺铁性贫血的诊断标准和治疗方法, 探讨口服铁剂的优缺点以及治疗中存在的争议, 并提出相应的补铁策略。Iron deficiency anemia(IDA)is one of the common complications of inflammatory bowel disease(IBD).Oral iron supplement is a commonly used treatment for IDA,and its role in IBD patients with IDA has always been controversial.There are problems such as oral iron intolerance and poor absorption in IBD patients.Studies showed that oral iron would increase the disease activity index in IBD patients,which may be related to oxidative stress induced by intestinal iron and change the composition of intestinal flora.This article summarizes the diagnostic criteria and treatment of IBD with IDA,explores the advantages and disadvantages of oral iron supplement and the treatment controversy,and puts forward iron supplement strategy.

关 键 词：炎症性肠病 贫血 缺铁性 铁剂 口服 铁吸收 

分 类 号：R574[医药卫生—消化系统] R556.3[医药卫生—内科学]