父母生育年龄与子代超重肥胖风险的关联  

Relationship between parental reproductive age and the risk of overweight and obesity in offspring

作　　者：邓睿 娄珂 周斯亮 李星秀 邹志勇[1] 马迎华[1] 马军[1] 董彬[1] Deng Rui;Lou Ke;Zhou Siliang;Li Xingxiu;Zou Zhiyong;Ma Yinghua;Ma Jun;Dong Bin(Institute of Child and Adolescent health,School of Public Health,Peking University,Beijing 100191,China)

机构地区：[1]北京大学公共卫生学院儿童青少年卫生研究所,北京100191

出　　处：《中华预防医学杂志》2022年第5期583-589,共7页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(81903344);2012年卫生公益性行业科研专项(201202010)。

摘　　要：目的探讨父母亲生育年龄与子代超重肥胖风险的关联。方法研究对象来源于在中国7省份开展的6~18岁学生体格检查数据,并采用问卷调查收集学生及其家长的人口学特征和生活方式相关信息。共纳入41567名资料完整的研究对象,根据限制性立方样条曲线将母亲生育年龄分为14~23、24~28、29~38岁三个类别,父亲生育年龄分为14~23、24~30、31~42岁三个类别,采用多因素logistic回归模型分析父母生育年龄和父母营养状态与子代超重肥胖发生风险的关联。结果41567名儿童的年龄为(10.6±3.2)岁,其父亲生育年龄为(27.9±4.4)岁,母亲生育年龄为(25.8±4.0)岁;儿童超重肥胖检出率为23.4%。调整儿童饮食行为因素后,父亲生育年龄为24~30岁和母亲生育年龄为24~28岁组子代超重肥胖风险OR(95%CI)值分别为1.11(1.04~1.18)、1.16(1.08~1.24)。父母双方均无超重肥胖的子代,肥胖风险差异无统计学意义;父母双方均超重肥胖时,父亲生育年龄为24~30岁组和母亲生育年龄为14~28岁组子代发生超重肥胖风险OR(95%CI)值分别为1.27(1.00~1.62)、1.33(1.07~1.65)。结论父母亲生育年龄和父母超重肥胖状态均与子代超重肥胖有关联,且存在交互作用。Objective To explore the role of parental reproductive age on the risk of overweight and obesity in offspring.Methods The participants were derived from physical examination data of students aged 6-18 years in seven provinces in China,and questionnaire survey was used to collect demographic characteristics and lifestyle information of the students and their parents.A total of 41567 children with complete data were included.According to the restricted cubic spline curve,maternal reproductive age was divided into three categories,14-23,24-28,and 29-38 years,and paternal reproductive age was divided into 14-23,24-30,and 31-42 years.Multivariate logistic regression model was used to analyze the association between parental reproductive age and parental nutritional status and the risk of overweight and obesity in offspring.Results The mean age of 41567 children was(10.6±3.2)years,and the mean paternal and maternal age were(27.9±4.4)years and(25.8±4.0)years,respectively.The detection rate of overweight and obesity was 23.4%.After adjusting factors of children diet and behaviors,the OR(95%CI)of offspring overweight and obesity in groups of fathers aged 24-30 years and mothers aged 24-28 years was 1.11(1.04-1.18)and 1.16(1.08-1.24),respectively.When none parents were overweight and obese,the difference of obesity risk was not statistically significant.When both parents were overweight and obese,the OR(95%CI)of offspring overweight and obesity in groups of fathers aged 24-30 years and mothers aged 14-28 years old was 1.27(1.00-1.62)and 1.33(1.07-1.65)respectively.Conclusion Parental reproductive age and parental overweight and obesity status may both increase the risk of overweight and obesity in offspring,with a significant interaction effect.

关 键 词：超重 肥胖症 青少年 横断面研究 生育年龄 

分 类 号：R723.14[医药卫生—儿科]