南京地区62家医疗机构心血管系统原研药和仿制药应用分析  

Application of Original and Generic Drugs for Cardiovascular System in 62 Medical Institutions in Nanjing

作　　者：周鹏 徐凯 戴惠珍 戴柔丽 李歆[1,4] ZHOU Peng;XU Kai;DAI Huizhen;DAI Rouli;LI Xin(School of Pharmacy,Nanjing Medical University,Nanjing 211100,China;Jiangsu Institute of Medical Information,Nanjing 210029,China;Dept.of Medical Affairs,the Fourth Affiliated Hospital of Nanjing Medical University,Nanjing 210000,China;Global Health Center,Nanjing Medical University,Nanjing 211100,China)

机构地区：[1]南京医科大学药学院,南京211100 [2]江苏省医药情报研究所,南京210029 [3]南京医科大学第四附属医院医务部,南京210000 [4]南京医科大学全球健康中心,南京211100

出　　处：《中国医院用药评价与分析》2022年第5期613-619,共7页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：江苏省卫生健康委2020年度医学科研立项项目(No.Z2020064)。

摘　　要：目的:了解南京地区心血管系统原研药和仿制药的使用情况,为医院合理用药和控制药品费用提出建议,以及为政策制定者制定相关政策提供理论依据。方法:从江苏省医药情报研究所提取数据,选取22种典型心血管系统用药,分析2016—2019年南京地区62家医疗机构目标药物的原研药和仿制药的平均用药频度(DDDs)占比、平均销售金额占比、价格比和仿制药替代原研药潜在费用节省率。结果:2016—2019年,南京地区62家医疗机构目标药物原研药和仿制药的平均DDDs占比分别为55.24%(319 824 440.25/578 978 334.11)和44.76%(259 153 893.86/578 978 334.11);平均销售金额占比分别为70.42%(1 723 436 924.96元/2 447 507 962.04元)和29.58%(724 071 037.08元/2 447 507 962.04元);原研药和仿制药的价格比为0.64~6.48,平均值为1.92,中位数为1.64;仿制药替代原研药平均每年可节省费用约1.50亿元,费用节省率达34.75%(598 877 162.06元/1 723 436 924.96元)。结论:22种心血管系统用药在南京市医疗机构占有的市场份额较少。医疗机构使用仿制药替代原研药可以节省大量费用。仿制药替代原研药进展缓慢,建议加快仿制药一致性评价,健全仿制药替代原研药制度,调整仿制药和非专利期原研药的价格结构,对医务工作者和患者普及仿制药相关政策,促进仿制药替代原研药,以节省医疗费用支出。OBJECTIVE: To investigate the application of original and generic drugs for cardiovascular system in Nanjing, and to put forward suggestions for rational drug application and drug cost control in hospitals, so as to provide theoretical basis for policy makers to formulate relevant policies, METHODS: Data were extracted from Jiangsu Institute of Medical Information, and 22 typical drugs for cardiovascular system were selected to analyze the proportion of defined daily dose system(DDDs), proportion of consumption sum, price ratio and potential cost saving rate of generic drugs replacing original drugs in 62 medical institutions in Nanjing from 2016 to 2019. RESULTS: From 2016 to 2019, the average proportion of DDDs for target drugs in 62 medical institutions in Nanjing were respectively 55.24%(319 824 440.25/578 978 334.11) and 44.76%(259 153 893.86/578 978 334.11), the average proportion of consumption sum was 70.42%(1 723 436 924.96 yuan/2 447 507 962.04 yuan) and 29.58%(724 071 037.08 yuan/2 447 507 962.04 yuan), and the price ratio was from 0.64 to 6.48, with an average of 1.92 and median of 1.64. Generic drugs could save an average of 150 million yuan per year by replacing the original drugs, and the cost saving rate was 34.75%(598 877 162.06 yuan/1 723 436 924.96 yuan). CONCLUSIONS: The 22 kinds of cardiovascular system drugs have a small market share in medical institutions of Nanjing. Healthcare providers can save a lot of money by using generic drugs instead of original drugs. Progress in the replacement of original drugs by generic drugs is slow, and it is recommended to speed up the evaluation of consistency of generic drugs, improve the system of replacement of original drugs for generic drugs, adjust the price structure of generic drugs and non-patented original drugs, popularize policies related to generic drugs for medical workers and patients, and promote the replacement of original drugs for generic drugs, so as to save medical expenses.

关 键 词：原研药 仿制药 替代 用药分析 心血管系统用药 

分 类 号：R972[医药卫生—药品]