甲状腺微小乳头状癌血浆和组织circRNA-102002的表达及其临床价值  

Expression of circRNA-102002 in Plasma and Tissues of Thyroid Micropapillary Carcinoma and Its Clinical Value

作　　者：符国宏[1] 王连臣[1] 陈旭 郑扬慈 FU Guo-hong;WANG Lian-chen;CHEN Xu;ZHENG Yang-ci(Department of General Surgery,Sanya Central Hospital/Hainan Third People’s Hospital,Hainan Sanya 572000,China)

机构地区：[1]三亚中心医院/海南省第三人民医院普外科,海南三亚572000

出　　处：《现代检验医学杂志》2022年第3期53-55,95,共4页Journal of Modern Laboratory Medicine

基　　金：海南省医药卫生科研基金项目(20A200043)。

摘　　要：目的探讨血浆和组织环状核糖核酸(circRNA)-102002在甲状腺微小乳头状癌(papillary thyroid microcarcinoma,PTMC)患者中的表达及其临床价值。方法选取三亚中心医院2018年1月~2020年12月收治的97例PTMC患者,将其分为淋巴结转移组(n=56)和无淋巴结转移组(n=41)。另选取同期45例体检正常者作为对照组。比较各组circRNA-102002表达水平,应用受试者工作特征曲线(ROC)分析circRNA-102002对PTMC诊断及预测淋巴结转移的价值。结果PTMC癌组织circRNA-102002表达水平(2.42±1.06)明显高于癌旁正常组织(0.56±0.12),差异有统计学意义(t=17.390,P<0.001)。PTMC组血浆circRNA-102002表达水平(2.08±0.93)明显高于对照组(0.31±0.08),差异有统计学意义(t=15.427,P<0.001)。淋巴结转移组血浆和组织circRNA102002表达水平(2.95±1.17,3.46±1.51)均明显高于无淋巴结转移组(1.24±0.43,1.35±0.58),差异有统计学意义(t=15.382,17.964,均P<0.001)。ROC曲线显示,血浆和组织circRNA-102002诊断PTMC的最佳截断值为1.37,1.58,其曲线下面积为0.810(95%CI:0.752~0.870)和0.850(95%CI:0.790~0.907);血浆和组织circRNA-102002诊断PTMC患者淋巴结转移的最佳截断值为2.27,2.65,其曲线下面积为0.857(95%CI:0.798~0.920)和0.891(95%CI:0.834~0.955)。结论circRNA-102002在PTMC患者中呈高表达,且与淋巴结转移有关,可作为PTMC诊断及预测淋巴结转移的参考指标。Objective To investigate the expression of circRNA-102002 in plasma and tissue in patients with papillary microcarcinoma of thyroid(PTMC)and its clinical significance.Methods 97 patients with PTMC treated in Sanya Central Hospital from January 2018 to December 2020 were selected and divided into lymph node metastasis group(n=56)and no lymph node metastasis group(n=41).Another 45 cases of normal physical examination in the same period were selected as the control group.The expression level of circRNA-102002 in each group was compared,and the value of circRNA-102002 in the diagnosis of PTMC and lymph node metastasis were analyzed by receiver operating characteristic(ROC)curve.Results The expression level of circRNA-102002 in PTMC tumor tissues(2.42±1.06)was significantly higher than that in adjacent normal tissues(0.56±0.12),the difference was statistically significant(t=17.390,P<0.001).The plasma circRNA-102002 expression level of PTMC group(2.08±0.93)was significantly higher than that of control group(0.31±0.08),the difference was statistically significant(t=15.427,P<0.001).The expression level of circRNA-102002 in plasma and tissue of the lymph node metastasis group(2.95±1.17,3.46±1.51)were significantly higher than that of the non-lymph node metastasis group(1.24±0.43,1.35±0.58),the differences were statistically significant(t=15.382,17.964,all P<0.001).ROC curves showed that the optimal cut-off values of plasma and tissue circRNA-102002 for PTMC diagnosis were 1.37,1.58,and the areas under the curve were 0.810(95%CI:0.752~0.870)and 0.850(95%CI:0.790~0.907),respectively.The optimal cut-off values of plasma and tissue circRNA-102002 for the diagnosis of lymph node metastasis in PTMC patients were 2.27,2.65,and the areas under the curve were 0.857(95%CI:0.798~0.920)and 0.891(95%CI:0.834~0.955)respectively.Conclusion circRNA-102002 was highlyexpressed in patients with PTMC and was associated with lymph node metastasis,which can be used as a reference index for the diagnosis and prediction of lymph node met

关 键 词：甲状腺微小乳头状癌 环状RNA-102002 

分 类 号：R736.1[医药卫生—肿瘤] R730.43[医药卫生—临床医学]