血浆S1P和HDL-C表达水平与帕金森病患者临床症状的相关性研究  

Correlation between Plasma S1P,HDL-C Expressions Levels and Clinical Symptoms in Patients with Parkinson’s Disease

作　　者：闫欣[1] 商素亮 李娜[1] 武娇 YAN Xin;SHANG Su-liang;LI Na;WU Jiao(Department of Neurology,the Second Central Hospital of Baoding City,Hebei Baoding 072750,China;Department of Geriatrics,the Eighth People’s Hospital of Hebei Province,Shijiazhuang 050000,China)

机构地区：[1]保定市第二中心医院神经内科,河北保定072750 [2]河北省第八人民医院老年科,石家庄050000

出　　处：《现代检验医学杂志》2022年第3期182-186,190,共6页Journal of Modern Laboratory Medicine

基　　金：河北省医学科学研究课题计划项目(编号20200267)。

摘　　要：目的分析帕金森病(Parkinson’s disease,PD)患者血浆鞘氨醇1磷酸(sphingosine 1 phosphate,S1P)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)表达水平,探讨二者与PD患者临床症状的关系。方法选择2018年7月~2021年3月于保定市第二中心医院确诊的PD患者100例作为研究对象(PD组),根据HoehnYahr分期将患者分为轻度组(1~2期)35例、中度组(2.5~3期)36例和重度组(4~5期)29例。另选取同期健康体检者105例为对照组。测定血浆S1P和HDL-C表达水平;比较不同严重程度PD患者运动症状及非运动症状评分;采用Pearson法分析PD患者血浆S1P和HDL-C表达水平与运动症状评分和非运动症状评分相关性;Logistic回归分析影响重度PD的危险因素。结果PD组患者血浆S1P(298.77±142.22 pmol/ml)和HDL-C(0.96±0.24 mmol/L)表达水平显著低于对照组(512.66±201.31 pmol/ml,1.87±0.33mmol/L),差异有统计学意义(t=8.744,20.327,均P=0.000)。轻度、中度和重度组血浆S1P(395.33±156.66 pmol/ml,290.73±142.60 pmol/ml,210.25±113.07 pmol/ml)与HDL-C(1.36±0.29 mmol/L,1.07±0.25 mmol/L,0.45±0.16 mmol/L)表达水平依次降低,差异有统计学意义(F=14.090,113.414,均P=0.000)。轻度组、中度组和重度组统一帕金森病评定量表第Ⅲ部分(unified parkinson’s disease rating scaleⅢ,UPDRSⅢ)评分(26.89±8.63分,43.11±16.66分,56.79±27.27分)、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分(12.35±3.96分,19.63±4.87分,25.18±5.17分)与汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分(8.86±2.67分,16.93±3.89分,26.79±5.83分)依次升高,差异均有统计学意义(F=20.648,61.097,146.366,均P=0.000)。简易精神状态检查(mini-mental state examination,MMSE)评分(23.67±4.37分,16.58±3.67分,12.06±2.15分)依次降低,差异有统计学意义(F=85.925,P=0.000)。PD组患者血浆S1P表达水平与HDL-C表达水平呈正相关(r=0.633,P=0.007),二者与UPDRSⅢ评分、HAMD评分和HAMA评分均呈负相关(r=-Objective To analyze the plasma levels of sphingosine1phosphate(S1P)and high density lipoprotein cholesterol(HDL-C)in patients with Parkinson’s disease(PD),and explore the relationship between them and clinical symptoms of PD.Methods 100 PD patients diagnosed in the Second Central Hospital of Baoding City from July 2018 to March 2021 were selected as the research objects(PD group).According to HoehnYahr stage,the patients were divided into mild group(stage 1~2)35 cases,moderate group(stage 2.5~3)36 cases and severe group(stage 4~5)29 cases.Another 105 healthy people were selected as control group,and plasma levels of S1P and HDL-C were measured.The scores of motor symptoms and non motor symptoms of PD patients with different severity were compared.Pearson method was used to analyze the correlation between plasma S1P,HDL-C levels and motor symptom score,non motor symptom score in PD patients,and Logistic regression analysis was used to analyze the risk factors of severe PD.Results The plasma S1P(298.77±142.22 pmol/ml),HDL-C(0.96±0.24 mmol/L)expression level in PD group was significantly lower than that in the control group(512.66±201.31 pmol/ml,1.87±0.33mmol/L),the differences were statistically significant(t=8.744,20.327,all P=0.000).The expression levels of plasma S1P(395.33±156.66 pmol/ml,290.73±142.60 pmol/ml,210.25±113.07 pmol/ml)and HDL-C(1.36±0.29 mmol/L,1.07±0.25 mmol/L,0.45±0.16 mmol/L)in mild,moderate and severe groups decreased in turn,the differences were statistically significant(F=14.090,113.414,all P=0.000).In mild,moderate and severe groups,the scores of Unified Parkinson’s disease rating scale Part Ⅲ(UPDRSⅢ)score(26.89±8.63 score,43.11±16.66 score,56.79±27.27 score),hamilton depression scale(HAMD)score(12.35±3.96 score,19.63±4.87 score,25.18±5.17 score),hamilton anxiety scale(HAMA)score(8.86±2.67 score,16.93±3.89 score,26.79±5.83 score)increased in turn,the differences were statistically significant(F=20.648,61.097,146.366,all P=0.000),the minimental state examination(MM

关 键 词：帕金森病 鞘氨醇1磷酸 高密度脂蛋白胆固醇 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R392.11[医药卫生—临床医学]