涎腺恶性多形性腺瘤11例临床病理分析  

Malignant pleomorphic adenoma of salivary gland:a clinicopathologic study of 11 cases

作　　者：辛颖 齐红[1,2,3] 李淑薇 张佳[1,2,3] 郭小梅 赵倩 XIN Ying;QI Hong;LI Shu-wei;ZHANG Jia;GUO Xiao-mei;ZHAO Qian(Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi’an Jiaotong University,Xi’an 710004,China;Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases,Xi’an 710199,China;Department of Pathology,College of Stomatology,Xi’an Jiaotong University,Xi’an 710004,China)

机构地区：[1]西安交通大学口腔医院/陕西省颅颌面精准医学研究重点实验室,西安710004 [2]陕西省牙颌疾病临床研究中心,西安710199 [3]西安交通大学口腔医院病理科,西安710004

出　　处：《临床与实验病理学杂志》2022年第4期448-451,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨恶性多形性腺瘤(malignant pleomorphic adenoma,MPA)的临床病理学特征。方法回顾性分析11例MPA的临床病理学及免疫表型特征,并复习相关文献。结果11例MPA发病年龄27~76岁,平均50岁,中位年龄53岁;男女比为6∶5。肿瘤部位:腮腺7例,颊部2例,腭部1例,咽旁1例;其中10例为原发性肿瘤,1例为复发性肿瘤。恶性成分的组织学类型包括:唾液腺导管癌4例,肌上皮癌3例,黏液表皮样癌2例,多形性腺癌1例,癌肉瘤1例。其中,侵袭性癌3例,非侵袭性癌8例。侵袭性癌中,2例发生颈部淋巴结转移,2例术后复发,1例死亡。非侵袭性癌中未出现淋巴结转移、复发或死亡。结论MPA多见于中老年男性,好发于腮腺。组织学通常同时具有良性多形性腺瘤成分和恶性肿瘤成分,恶性成分多为唾液腺导管癌和肌上皮癌,侵袭性癌易发生颈部淋巴结转移、复发和死亡。Purpose To analyze the clinicopathologic features of salivary malignant pleomorphic adenoma(MPA).Methods The clinical and pathological characteristics of 11 MPAs were collected.The pathological features were analyzed by HE and immunohistochemical staining,and the relevant literature were reviewed.Results Of the 11 MPA cases,7 were in the parotid gland,2 in the cheek,1 in the palate,and 1 in the pharynx.The mean age was 50 years(from 27 to 76),and the median age was 53 years.The ratio of men to women was 6∶5.Of the 11 MPA cases,10 were primary tumors,1 was recurrent tumor.The histological types of malignant components included salivary duct carcinoma in 4,myoepithelial carcinoma in 3,mucoepidermoid carcinoma in 2,pleomorphous adenocarcinoma in 1,and carcinosarcoma in 1.There were 3 cases of invasive carcinoma and 8 cases of non-invasive carcinoma.In invasive carcinoma,2 cases had cervical lymph node metastasis,2 cases recurred after operation,and 1 case died.There was no lymph node metastasis,recurrence,or death in non-invasive carcinoma.Conclusion MPA is more common in middle-aged and elderly males,mostly in the parotid gland.Both benign pleomorphic adenoma and malignant tumor can be found in most MPA.Most of the malignant components are salivary gland ductal carcinoma and myoepithelial carcinoma.Invasive carcinoma is prone to cervical lymph node metastasis,recurrence and death.

关 键 词：涎腺肿瘤 恶性多形性腺瘤 多形性腺瘤癌变 临床病理特征 

分 类 号：R739.8[医药卫生—肿瘤]