高甘油三酯血症性急性胰腺炎的发病机制研究进展  

Research progress on the pathogenesis of hypertriglyceridemia-related acute pancreatitis

作　　者：王池 段丽芳 许小凡 张红[1,3] Wang Chi;Duan Li-Fang;Xu Xiao-Fan;Zhang Hong(Basic Medical Academy,,Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi 712046,China;Medical Experiment Center,,Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi 712046,China;Shaanxi International Cooperation Base/International Joint Research Center for Prevention and Treatment of Immune Inflammation Related Diseases with Traditional Chinese Medicine,Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi 712046,China)

机构地区：[1]陕西中医药大学基础医学院,陕西咸阳712046 [2]陕西中医药大学医学科研实验中心,陕西咸阳712046 [3]陕西中医药大学陕西省国际合作基地/免疫炎症相关疾病中医药防治国际联合研究中心,陕西咸阳712046

出　　处：《解放军医学杂志》2022年第5期500-505,共6页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(81603420);陕西省科技厅自然科学基础研究计划(2017JM8076)。

摘　　要：近年来,随着人们生活方式及饮食结构的改变,高甘油三酯血症(HTG)成为引发急性胰腺炎(AP)或导致AP病情加重的重要原因。有研究指出HTG已成为继胆道疾病之后引起AP的第二大因素,提出了高甘油三酯血症性急性胰腺炎(HTG-AP)的概念,并对其进行了大量探索。至今高甘油三酯血症参与AP进展的机制尚未明确,导致临床治疗缺乏靶点。当前亟须认识HTG-AP的机制,以为其治疗提供新的思路。本文就HTG-AP的相关发病机制包括过多的游离脂肪酸(FFA)引起氧化应激、Ca^(2+)超载、内质网应激及微循环障碍等进行综述。With the change of people's lifestyle and diet structure,hypertriglyceridemia(HTG)has gradually become an important factor causing or aggravating acute pancreatitis(AP).Some studies have pointed out that HTG has become the second major factor of AP following biliary diseases.The concept of hypertriglyceridemic-related acute pancreatitis(HTG-AP)has been put forward,and a large number of studies have been carried out on its mechanism.However,the mechanism of hypertriglyceridemia involved in the progression of AP is still unclear,leading to the lack of specific targets for treatment.This article reviews the pathogenesis of HTG-AP,including excessive free fatty acids(FFA)-induced oxidative stress,Ca^(2+)overload,endoplasmic reticulum stress,microcirculatory disturbance,etc.

关 键 词：高甘油三酯血症 急性胰腺炎 发病机制 

分 类 号：R363[医药卫生—病理学] R576[医药卫生—基础医学]