术前动脉介入化疗治疗早期巨块型宫颈癌的临床效果观察  

Clinical effect of preoperative arterial interventional chemotherapy in the treatment of early massive cervical carcinoma

作　　者：李敏 梁攀 陈慧子 LI Min;LIANG Pan;CHEN Hui-zi(Department of Obstetrics and Gynecology,General Hospital of Yongmei Group,Shangqiu 476600,Henan,China;Department of Obstetrics and Gynecology,General Hospital of Shenhuo Group,Shangqiu,Henan;Department of Obstetrics and Gynecology,Yongcheng People's Hospital)

机构地区：[1]永煤集团总医院妇产科,河南商丘476600 [2]河南商丘神火集团总医院妇产科 [3]永城市人民医院妇产科

出　　处：《青岛医药卫生》2022年第3期161-165,共5页Qingdao Medical Journal

摘　　要：目的探讨术前动脉介入化疗治疗早期巨块型宫颈癌的临床效果和安全性。方法选择2018年2月至2020年2月本院收治的早期巨块型宫颈癌患者92例,随机分为对照组和观察组各46例,对照组给予全身静脉化疗,观察组给予动脉介入化疗,28 d为1个疗程,两组均连续化疗3个疗程。比较两组治疗后的临床疗效、手术时间、出血量、根治性手术率、淋巴结转移率、血管内皮生长因子D、血管内皮生长因子C、血管内皮生长因子A水平、生存质量及恶心、呕吐、骨髓抑制、神经毒性等不良反应发生情况。结果观察组临床总有效率高于对照组,手术时间短于对照组,出血量少于对照组,根治性手术率高于对照组,淋巴结转移率低于对照组(P<0.05),两组治疗前血管内皮生长因子D、血管内皮生长因子C、血管内皮生长因子A水平差异无统计学意义(P>0.05),治疗后两组血管内皮生长因子D、血管内皮生长因子C、血管内皮生长因子A水平均下降,观察组低于对照组(P<0.05);治疗后两组生存质量评分均升高,观察组高于对照组(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论术前动脉介入化疗治疗早期巨块型宫颈癌临床疗效优于全身静脉化疗,可有效提高患者根治性手术率,改善血管内皮功能,提高生存质量。Objective To investigate the clinical efficacy and safety of preoperative arterial interventional chemotherapy in the treatment of early massive cervical carcinoma.Methods A total of 92 patients with early massive cervical cancer admitted to our hospital from February 2018 to February 2020 were randomly divided into control group and observation group,with 46 cases in each group.The control group was given systemic intravenous chemotherapy,and the observation group was given arterial interventional chemotherapy,28 days as a course of chemotherapy,3 consecutive courses of chemotherapy in both groups.The clinical efficacy,operative time,blood loss,radical surgery rate,rate of lymph node metastasis,vascular endothelial growth factor D,vascular endothelial growth factor C,vascular endothelial growth factor A level,quality of life and nausea,vomiting,bone marrow suppression,neurotoxicity and other adverse reactions of two groups after treatment were compared.Results The total clinical effective rate in the observation group was higher than that in the control group,the operation time was shorter than that in the control group,the amount of blood loss was less than that in the control group,the radical operation rate was higher than that in the control group,and the lymph node metastasis rate was lower than that in the control group(P<0.05).Before treatment,there was no statistically significant difference in vascular endothelial growth factor D,vascular endothelial growth factor C,and vascular endothelial growth factor A(P>0.05),after treatment,levels of them were decreased,observation group was lower than control group(P<0.05).After treatment,quality of life score of two groups were increased,observation group was higher than control group(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion The clinical efficacy of preoperative arterial interventional chemotherapy in the treatment of early massive cervical cancer is better than systemic intravenous c

关 键 词：巨块型宫颈癌 动脉介入化疗 全身静脉化疗 血管内皮功能 不良反应 

分 类 号：R737.33[医药卫生—肿瘤]