血管内介入栓塞术对隐匿性脑血管畸形出血患者临床疗效及VEGF、LP、Ang1、Ang2的影响  

Effect of Endovascular Interventional Embolization on Clinical Efficacy,VEGF,LP,Ang1,Ang2 in Patients with Occult Cerebral Vascular Malformation and Hemorrhage

作　　者：朱轲 ZHU Ke(Department of Intervention,Yongmei Group General Hospital,Yongcheng 476600,Henan Province,China)

机构地区：[1]河南省永城市永煤集团总医院介入科,河南永城476600

出　　处：《罕少疾病杂志》2022年第7期20-21,35,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨隐匿性脑血管畸形(OVMS)出血患者给予血管内介入栓塞术治疗的临床疗效及对瘦素(LP)、血管内皮生长因子(VEGF)、血管生成素1(Ang1)、血管生成素2(Ang2)的影响。方法选取2018年6月至2021年8月在永煤集团总医院治疗的OVMS出血患者共计88例,按照随机摸球法分成A组(n=44)和B组(n=44),B组给予传统畸形血管切除术,A组给予血管内介入栓塞术,统计临床疗效,比较两组VEGF、LP、Ang1、Ang2变化情况。结果A组(95.45%)治疗总有效率较B组(79.55%)明显更高(P<0.05);两组术后VEGF、LP、Ang2水平明显降低(P<0.05),Ang1水平明显提高(P<0.05),与B组相比,A组VEGF、LP、Ang2水平明显更低(P<0.05),Ang1水平明显更高(P<0.05)。结论对OVMS出血患者给予血管内介入栓塞术治疗,能够促进临床疗效的提高,对血管内皮功能及LP、Ang1、Ang2的改善具有重要作用。Objective To investigate the effects of endovascular interventional embolization on the clinical efficacy and vascular endothelial growth factor(VEGF),leptin(LP),angiopoietic hormone 1(ANG1)and angiopoietic hormone 2(ANG2)in patients with occult intracranial vascular malformations(OVMS)bleeding.Methods Eighty-eight patients with OVMS bleeding who were treated at Yongmei Group General Hospital from June 2018 to August 2021 were selected,and they were divided into group A(n=44)and group B(n=44)by the random touching ball method.Group B was treated with traditional malformation vascular resection,and group A was treated with endovascular embolization.The clinical efficacy,VEGF,LP,Ang1,and Ang2 changes were compared between the two groups.Results Compared with group B(79.55%),the total effective rate of group A(95.45%)was significantly higher(P<0.05).Compared with group B,the levels of VEGF,LP and Ang2 in group A were significantly lower(P<0.05),and the levels of Ang1 were significantly higher(P<0.05).Conclusion Endovascular interventional embolization in patients with OVMS bleeding can promote the improvement of clinical efficacy and play an important role in the improvement of vascular endothelial function and LP,Ang1,and Ang2.

关 键 词：血管内介入栓塞术 隐匿性脑血管畸形出血 临床疗效 血管内皮生长因子 瘦素 血管生成素 

分 类 号：R743.4[医药卫生—神经病学与精神病学]