杞菊地黄丸联合重组人表皮生长因子衍生物滴眼液治疗白内障术后干眼症的效果  

Effect of Qiju Dihuang Pills Combined with Recombinant Human Epidermal Growth Factor Derivative Eye Drops in the Treatment of Dry Eye after Cataract Surgery

作　　者：闫俊茹 张明华 张甦琦 YAN Jun-ru;ZHANG Ming-hua;ZHANG Su-qi(Department of Ophthalmology,Zhumadian Eye Hospital,Zhumadian 463000,Henan Province,China;Department of Ophthalmology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China)

机构地区：[1]驻马店眼科医院眼科,河南驻马店463000 [2]河南科技大学第一附属医院眼科,河南洛阳471000

出　　处：《罕少疾病杂志》2022年第7期28-29,38,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨杞菊地黄丸联合重组人表皮生长因子衍生物滴眼液治疗白内障术后干眼症的效果。方法收集2020年6月至2021年6月在本院就诊的白内障术后干眼症患者102例,采用随机数字表法进行分组,即对照组、观察组,均51例(均51眼)。对照组采用重组人表皮生长因子衍生物滴眼液,每次1滴,每天治疗3次;观察组在对照组的基础上增加杞菊地黄丸,每次予以8丸,每天2次,共12周。结果干预前,两组中医临床症状评分比较,P>0.05;干预后,两组中医临床症状评分均显著低于干预前,P<0.05,进一步组间比较,观察组中医临床症状评分均显著低于对照组,P<0.05。干预前,两组FLS评分、BUT、Slt比较,P>0.05;干预后,两组FLS评分均显著低于干预前,BUT、Slt显著高于干预前,P<0.05,进一步组间比较,观察组FLS评分显著低于对照组,BUT、Slt显著高于对照组,P<0.05。观察组临床有效率92.16%显著高于对照组,P<0.05。两组均未发生不良反应。结论杞菊地黄丸联合重组人表皮生长因子衍生物滴眼液治疗白内障术后干眼症,效果理想,可有效缓解临床症状,提高泪膜的稳定性,安全性高。Objective To investigate the effect of Qiju Dihuang Pills combined with recombinant human epidermal growth factor derivative eye drops in the treatment of dry eye after cataract surgery.Methods A total of 102 patients with dry eye after cataract surgery who were treated in our hospital from June 2020 to June 2021 were collected and divided into groups by random number table method,namely the control group and the observation group,with 51 cases(both 51 eyes).The control group was treated with recombinant human epidermal growth factor derivative eye drops,1 drop each time,3 times a day;the observation group was treated with Qiju Dihuang Pills on the basis of the control group,8 pills each time,2 times a day,for a total of 12 weeks.Results Before the intervention,the TCM clinical symptom scores of the two groups were compared,P>0.05;after the intervention,the TCM clinical symptom scores of the two groups were significantly lower than those before the intervention,P<0.05.Further comparison between the groups showed that the TCM clinical symptom scores of the observation group were significantly lower than the control group,P<0.05.Before the intervention,the FLS scores,BUT,and Slt of the two groups were compared,P>0.05;after the intervention,the FLS scores of the two groups were significantly lower than those before the intervention,and the BUT and Slt were significantly higher than those before the intervention,P<0.05.Further comparison between the two groups showed that the FLS score in the observation group was significantly lower than that in the control group,and the BUT and Slt were significantly higher than those in the control group,P<0.05.The clinical effective rate of the observation group was 92.16%,which was significantly higher than that of the control group,P<0.05.There were no adverse reactions in both groups.Conclusion Qiju Dihuang Pills combined with recombinant human epidermal growth factor derivative eye drops in the treatment of dry eye after cataract surgery has an ideal effect,can effectively re

关 键 词：白内障 干眼症 杞菊地黄丸 重组人表皮生长因子衍生物 安全性 

分 类 号：R776.1[医药卫生—眼科]