精神分裂症患者的肠道微生物结构特征和功能预测  

Structural Characteristics and Functional Prediction of Intestinal Microorganisms in Patients with Schizophrenia

作　　者：凌秋 谢新晖 杨和增[3] 赖文涛 赵杰[3] 刘泱慧 荣晗 LING Qiu;XIE Xin-hui;YANG He-zeng;LAI Wen-tao;ZHAO Jie;LIU Yang-hui;RONG Han(Shenzhen Mental Health Clinical College of Anhui Medical University,Shenzhen 518020,Guangdong Province,China;Renmin Hospital of Wuhan University,Wuhan 430060,Hubei Province,China;Shenzhen Mental Health Center/Shenzhen Kangning Hospital,Shenzhen 518020,Guangdong Province,China)

机构地区：[1]安徽医科大学深圳精神卫生临床学院,广东深圳518020 [2]武汉大学人民医院,湖北武汉430060 [3]深圳市精神卫生中心/深圳市康宁医院,广东深圳518020

出　　处：《罕少疾病杂志》2022年第7期88-93,共6页Journal of Rare and Uncommon Diseases

基　　金：广东省高水平临床重点专科(深圳市配套建设经费)资助(SZGSP013);深圳市医疗卫生三名工程资助项目(SZSM201812052)

摘　　要：目的探究精神分裂症患者肠道微生物结构特征与功能预测。方法最终纳入2019年10月至2020年12月在深圳市康宁医院住院的精神分裂症患者19名作为精神分裂症(SCZ)组和同时期周边社区的健康志愿者52名作为健康对照(HC)组(按1:3的比例)。运用16S RNA技术分析两组肠道微生物结构特征和进行功能预测。结果(1)SCZ组和HC组的肠道微生物结构特征的差异具有统计学意义,在科、属、种三个水平上共找到8个差异的菌,在科水平有疣微菌科和毛螺菌科;在属水平为粪杆菌属、Butyricicoccus、毛螺菌属、氏菌属及杆菌属;在种水平有普拉梭菌、Butyricicoccus pullicaecorum和Roseburia faecis。(2)SCZ组和HC组在KEGG功能预测发现,两组样本在KEGG L1、KEGG L2、KEGG L3的部分功能预测的差异具有统计学意义。结论精神分裂症患者肠道微生物结构特征与健康对照相比发生改变,部分肠道微生物特征可能会成为精神分裂症临床诊断的辅助依据之一。Objective To explore the structural characteristics and functional prediction of gut microbiota in patients with schizophrenia.Methods Nineteen schizophrenia patients hospitalized in Shenzhen Kangning Hospital from October 2019 to December 2020 were included as schizophrenia(SCZ)group and fifty-two healthy volunteers from surrounding communities during the same period were included as healthy control(HC)group(In a ratio of 1 to 3).16S RNA technology was used to analyze the structural characteristics of two groups of intestinal microorganisms and make functional predictions.Results The structural characteristics of the gut microbiome in the SCZ group and the HC group were different and statistically significant.A total of 8 different bacterial groups were found at different classification levels.At the family level there were Verructomycetaceae and Lachnospiraceae.At the genus level there were Faecalibacterium,Butyricicoccus,Butyricicoccus,Lachnospira,Roseburia,Dialister.At the species level there are Faecalibacterium prausnitzii,Butyricicoccus pullicaecorum and Roseburia faecis.Conclusion Compared with healthy controls,the structural characteristics of gut microbes in patients with schizophrenia are changed,and some of the characteristics of gut microbes may become one of the auxiliary evidences for the clinical diagnosis of schizophrenia.

关 键 词：精神分裂症 肠道微生物 16S RNA 

分 类 号：R749.3[医药卫生—神经病学与精神病学]