Periostin在妇科恶性肿瘤中的研究现状  

Research status of periostin in gynecological malignancies

作　　者：初磊[1] 郭翼[1] 童晓文[1] Chu Lei;Guo Yi;Tong Xiaowen(Department of Obstetrics and Gynecology,Tongji Hospital of Tongji University,Shanghai 200065,China)

机构地区：[1]同济大学附属同济医院妇产科,上海200065

出　　处：《中华妇幼临床医学杂志（电子版）》2022年第2期145-149,共5页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：国家自然科学基金项目(81802583)。

摘　　要：骨膜蛋白(periostin)是近年被发现的一种多功能高分子糖蛋白,主要由成骨细胞及其前体细胞分泌,也可由肿瘤细胞及癌旁细胞分泌。该蛋白是一种高度保守的功能蛋白质,参与细胞外基质(ECM)的组成,并与肿瘤细胞黏附、转移和生长密切相关,属于分泌型可溶性ECM蛋白。periostin促进肿瘤细胞生存的分子机制及其与肿瘤发生、发展的关系具有重要理论意义,而且可为肿瘤的临床检测和治疗提供新靶点。笔者拟就periostin的结构与功能,periostin高表达在妇科恶性肿瘤发生、发展中的作用机制,在卵巢癌、宫颈癌、子宫内膜癌的初步研究,以及periostin为肿瘤治疗提供新靶点等的最新研究进展进行阐述。Periostin is a kind of multifunctional macromolecular glycoprotein discovered in recent years.It is mainly secreted by osteoblasts and their precursor cells,and can also be secreted by tumor cells and para-carcinoma cells.Periostin is a highly conserved functional protein,which participates in the formation of extracellular matrix(ECM)and is closely related to tumor cell adhesion,metastasis and growth.It is a secreted soluble ECM protein.There is great theoretical value to explore the molecular mechanism of periostin promoting tumor cell survival and its relationship with tumor occurrence and development.The findings can provide new targets for clinical detection and treatment of tumors.The author intends to review the structure and function of periostin,mechanism of highly expressed periostin in the occurrence and development of gynecological malignancies,preliminary research on highly expressed periostion in ovarian cancer,cervical cancer,and endometrial cancer,and the new target of periostin for tumor therapy.

关 键 词：细胞外基质 PERIOSTIN 细胞外基质蛋白质类 卵巢肿瘤 宫颈肿瘤 子宫内膜肿瘤 间质细胞 分子靶向治疗 生殖器肿瘤 女(雌)性 

分 类 号：R73[医药卫生—肿瘤]