进展期肝细胞癌采取放疗辅以体外局部高热热疗对疗效、生存期的影响  

Influence of Radiotherapy Combined with Extracorporeal Local Hyperthermia on Curative Effect and Survival in Advanced Hepatocellular Carcinoma

作　　者：林丽[1] 王靓 刘银凤 陈彩霞 陈珍文 何朝光 LIN Li;WANG Liang;LIU Yinfeng;CHEN Caixia;CHEN Zhenwen;HE Chaoguang(Department of Radiotherapy,Fujian Medical University Cancer Hospital,Fuzhou 350014,China)

机构地区：[1]福建医科大学附属肿瘤医院放疗科,福建福州350014

出　　处：《中国医药指南》2022年第17期13-16,共4页Guide of China Medicine

摘　　要：目的探析为进展期肝细胞癌患者采取放疗辅以体外局部高热热疗对患者病情疗效及生存期的影响。方法纳入2019年1月至2020年1月在本院接受治疗被确诊为进展期肝细胞癌患者60例,以随机数字表法将患者分为对照组、观察组,各30例。对照组单纯用放疗治疗,观察组配合体外局部高热热疗干预措施。在为期12个月随访后对两组患者疗效、肝功能指标、血清肿瘤标志物、相关不良反应以及生存期情况进行比较,归纳二者联合治疗对患者的临床价值。结果观察组患者病情有效缓解率高于对照组,差异有统计学意义(P<0.05)。治疗前,观察组患者血浆丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、血清总胆红素(TBIL)指标,差异无统计学意义(P>0.05);观察组患者治疗后各项肝功能指标低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者血清甲胎蛋白(AFP)、甲胎蛋白异质体L3(AFP-L3)、高尔基糖蛋白-73(GP73)、血管内皮生长因子(VEGF)指标比较,差异无统计学意义(P>0.05);观察组患者治疗后各项指标低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者不良反应事件中放射性肝损伤比例低于对照组,差异有统计学意义(P<0.05)。在末次随访时,观察组患者的生存率高于对照组,差异有统计学意义(P<0.05)。结论对进展期肝细胞癌患者在放疗干预基础上联合体外局部高热热疗对于提升病情控制效果,改善肝功能及肿瘤标志物指标有积极的价值,能有效延长患者的生存期。Objective To explore the effect of radiotherapy combined with extracorporeal local hyperthermia on the curative effect and survival of patients with advanced hepatocellular carcinoma.Methods A total of 60 patients with advanced hepatocellular carcinoma who received treatment in our hospital from January 2019 to January 2020 were included.The patients were divided into the control group and the observation group by random number table,with 30 cases in each group.The control group was treated with radiotherapy alone,and the observation group was combined with extracorporeal local hyperthermia intervention.After a 12-month follow-up,the curative effect,liver function indexes,serum tumor markers,related complications and survival time of the two groups of patients were compared,and the clinical value of the combination of the two was summarized.Results The effective remission rate of patients in the observation group was higher than that in the control group,with statistical significance(P<0.05).Before treatment,there was no statistical difference in plasma alanine aminotransferase(ALT),aspartate aminotransferase(AST)and serum total bilirubin(TBIL)in the observation group(P>0.05).The functional index was lower than that of the control group,with statistical significance(P<0.05).Before treatment,there were no significant differences in serum alpha-fetoprotein(AFP),alpha-fetoprotein L3(AFP-L3),golgi glycoprotein-73(GP73)and vascular endothelial growth factor(VEGF)indexes between the two groups(P>0.05),the indexes in the observation group after treatment were lower than those in the control group,with statistical significance(P<0.05).After treatment,the number of radioactive liver injury cases in the observation group was lower than that in the control group,with statistical significance(P<0.05).At the last follow-up,the survival rate of the observation group was higher than that of the control group,with statistical significance(P<0.05).Conclusion For patients with advanced hepatocellular carcinoma,the combination of e

关 键 词：进展期肝细胞癌 放疗 体外局部高热热疗 肝功能 肿瘤标志物 生存期 

分 类 号：R735.7[医药卫生—肿瘤]