血清可溶性CD40配体、脂蛋白相关的磷脂酶A2水平与老年急性脑梗死的相关性  

Correlation between serum levels of soluble CD40 ligand and lipoprotein-associated phospholipase A2 in elderly patients with acute cerebral infarction

作　　者：蒋洋波 王权 季敏 姜文 郑锡凤 王文玥 高伟 JIANG Yangbo;WANG Quan;JI Min;JIANG Wen;ZHENG Xifeng;WANG Wenyue;GAO Wei(Dept.of Geriatrics,Sir Run Run Hospital Affiliated to Nanjing Medical University,Nanjing 211100,Jiangsu,China)

机构地区：[1]南京医科大学附属逸夫医院老年医学科,江苏南京211100

出　　处：《武汉大学学报（医学版）》2022年第3期475-479,共5页Medical Journal of Wuhan University

摘　　要：目的:探讨血清中可溶性CD40配体(sCD40L)和脂蛋白相关的磷脂酶A2(Lp-PLA2)水平与老年急性脑梗死的相关性。方法:选取在南京医科大学附属逸夫医院老年科住院治疗的80例脑梗死患者,均经头颅MRA+MRI证实为前循环脑梗死患者(脑梗死组);另选取老年健康志愿者30例,为对照组。应用全自动酶标仪检测血清中sCD40L水平,常规测定总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)等指标,血清Lp-PLA2测定采用双抗体夹心免疫层析法分析。结果:两组在年龄、性别、吸烟史、糖尿病史、总胆固醇、甘油三酯等方面无统计学差异(P>0.05);而脑梗死组sCD40L、Lp-PLA2、LDL-C水平高于对照组(P<0.05);脑梗死组血清中的黏附分子与蛋白酶分子含量高于对照组(P<0.05)。在较高水平sCD40L、Lp-PLA2的脑梗死患者中,其黏附分子与蛋白酶分子含量明显高于低水平梗死患者(P<0.05)。结论:血清可溶性CD40配体及脂蛋白相关磷脂酶A2升高与脑梗死的发生及病情严重程度相关。Objective:To investigate the correlation between serum levels of soluble CD40 ligand(sCD40L)and lipoprotein-associated phospholipase A2(Lp-PLA2)in elderly patients with acute cerebral infarction.Methods:Eighty patients with cerebral infarction who were hospitalized in the department of neurology of Sir Run Run Hospital Affiliated to Nanjing Medical University were enrolled in this study.All patients were diagnosed as anterior circulation cerebral infarction by MRA+MRI.Blood samples were collected by automatic microplate reader to detect serum sCD40L levels;blood Lp-PLA2 was assayed by double antibody sandwich immunochromatography analysis;the indices such as total cholesterol,triglycerides,LDL-C,etc.,were also determined.Thirty health elderly volunteers were involved as control group.Results:No significant difference was found in age,gender,smoking history,diabetes history,and serum levels of total cholesterol and triglycerides.The levels of sCD40L,Lp-PLA2,and LDL-C in cerebral infarction group were higher than in control group(P<0.05).The serum adhesion molecules and protease molecules in the cerebral infarction group were higher than in control group(P<0.05).In cerebral infarction patients with the high levels of sCD40L and Lp-PLA2,the content of adhesion molecules and protease molecules were significantly higher than in the patients with low levels of sCD40L and Lp-PLA2(P<0.05).Conclusion:The serum sCD40L and Lp-PLA2 levels are associated with the occurrence of cerebral infarction and the severity of the disease.

关 键 词：老年 脑梗死 可溶性CD40配体 脂蛋白相关磷脂酶A2 

分 类 号：R743.5[医药卫生—神经病学与精神病学]