甲苯磺酸瑞马唑仑联合舒芬太尼在老年患者无痛结直肠镜镇静中的有效性和安全性  

Efficacy and safety of remimazolam tosylate combined with sufentanil for elderly patients undergoing colonoscopy sedation

作　　者：李思彤 张毅[1] 叶刚 向俊 牟俊英 姚娜娜 朱贤林 LI Sitong;ZHANG Yi;YE Gang;XIANG Jun;MOU Junying;YAO Nana;ZHU Xianlin(Hubei University of Medicine,Shiyan 442000,Hubei,China;Dept.of Anesthesiology,The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi 445000,Hubei,China)

机构地区：[1]湖北医药学院,湖北十堰442000 [2]恩施土家族苗族自治州中心医院麻醉科,湖北恩施445000

出　　处：《武汉大学学报（医学版）》2022年第3期480-484,共5页Medical Journal of Wuhan University

基　　金：湖北陈孝平科技发展基金会临床研究专项基金(编号:cxp JJH12000005-07-20)。

摘　　要：目的:研究甲苯磺酸瑞马唑仑(简称瑞马唑仑)联合舒芬太尼在老年患者无痛结直肠镜镇静中应用的有效性和安全性。方法:选择门诊预约无痛结直肠镜检查的患者76例,随机分为试验组(瑞马唑仑组)和对照组(丙泊酚组),每组38例。患者入室后常规监测心率(HR)、血压(BP)和脉搏氧饱和度(SpO_(2)),采用改良警觉/镇静性评分(MOAA/S)评估患者镇静深度,观察两组患者镇静成功率、麻醉苏醒时间,并记录两组患者镇静期间低血压、呼吸抑制、恶心、呕吐等不良事件发生率。结果:瑞马唑仑组与丙泊酚组镇静成功率都是100.0%,但瑞马唑仑组的苏醒时间明显更短(P<0.05);瑞马唑仑组患者镇静期间低血压、呼吸抑制、恶心、呕吐等不良事件发生率明显低于丙泊酚组(P<0.05)。结论:甲苯磺酸瑞马唑仑用于老年患者无痛结直肠镜麻醉,其镇静有效性和安全性均较高。Objective:To study the effectiveness and safety of remimazolam tosylate combined with sufentanil for elderly patients in painless colonoscopy sedation.Methods:A total of 76 elderly patients with elective painless colonoscopy procedures in outpatient department were randomly divided into experimental group(remimazolam group)and control group(propofol group),with 38 cases in each group.After the patients entered the room,the heart rate(HR),blood pressure(BP),and pulse oxygen saturation(SpO_(2))were routinely monitored,and the modified alertness/sedation score(MOAA/S)was used to assess the depth of sedation.The success rate of sedation,awakening time,the incidence of adverse events such as hypotension,respiratory depression,nausea,and vomiting during sedation were recorded and compared between the two groups.Results:Compared with that respectively in the propofol group,the same success rate of sedation(100%)was found in remimazolam group,but the awakening time in remimazolam group was significantly shorter(P<0.05).The incidence of adverse events such as hypotension,respiratory depression,nausea and vomiting during sedation in the remimazolam group was significantly lower than that in the propofol group,and the difference was statistically significant(P<0.05).Conclusion:Remimazolam tosylate is recommended to painless colonoscopy sedation and has high sedative efficacy and safety.

关 键 词：瑞马唑仑 丙泊酚 结直肠镜 低血压 呼吸抑制 

分 类 号：R574.62[医药卫生—消化系统]