双相障碍抑郁发作与抑郁症患者血清SP、Glu与BDNF水平变化及意义  

Changes and significance of serum SP,Glu and BDNF levels in patients with depressive episodes of bipolar disorder and depression

作　　者：蒋燕升 雷秀雯 仲照希 JIANG Yansheng;LEI Xiuwen;ZHONG Zhaoxi(The 9th Department of Psychiatry(Depression Ward),Luoyang Fifth People's Hospital,Luoyang,Henan,China,471000)

机构地区：[1]洛阳市第五人民医院精神九科(抑郁症病区),河南洛阳471000

出　　处：《分子诊断与治疗杂志》2022年第5期769-772,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省自然科学基金(182300410317);河南省基础与前沿技术研究计划项目资助(152300410121)。

摘　　要：目的探讨双相障碍抑郁发作与抑郁症患者血清P物质(SP)、谷氨酸(Glu)与脑源性神经营养因子(BDNF)水平差异。方法选择2018年2月至2021年2月新乡医学院第二附属医院收治的双相障碍抑郁发作患者(双相抑郁组)42例和抑郁症患者(抑郁症组)74例作为观察对象,另选取同期体检的健康志愿者(对照组)36例。采用酶联免疫吸附法检测研究对象血清SP、Glu、BDNF水平,采用汉密尔顿抑郁量表(HAMD⁃17)、汉密尔顿焦虑量表(HAMA)评定抑郁症状,采用受试者工作特征曲线(ROC)分析血清SP、Glu、BDNF、临床症状评分对双相障碍抑郁的诊断价值。结果三组间研究对象的性别比例、年龄、本次病程、发病年龄、受教育年限比较,差异无统计学意义(P>0.05)。三组血清SP、HAMD、HAMA评分比较:抑郁症组>双相抑郁组>对照组,差异有统计学意义(P<0.05);BDNF水平比较:对照组>抑郁组>双相抑郁组,差异有统计学意义(P<0.05);血清Glu水平比较:双相抑郁组>抑郁症组>对照组,差异有统计学意义(P<0.05)。经ROC分析,血清SP、BDNF及症状评分HAMD、HAMA联合检测AUC值为0.906,优于单一检测(P<0.05)。结论双相障碍抑郁与抑郁症血清指标SP、Glu、BDNF紊乱,且双相障碍抑郁患者血清指标紊乱程度和焦虑抑郁症状更严重,联合检测可作为区别诊断的有利手段。Objective To investigate the serum levels of substance P(SP),glutamic acid(Glu)and brain⁃derived neurotrophic factor(BDNF)in patients with depressive episodes and depression in bipolar disorder difference.Methods From February 2018 to February 2021,42 patients with depressive episodes of bipolar disorder(bipolar depression group)and 74 patients with depression(depression group)in the Second Affiliated Hospital of Xinxiang Medical College were selected as the observation objects.Thirty⁃six healthy volunteers(control group)were examined during the same period.The serum levels of SP,Glu,and BDNF were detected by enzyme⁃linked immunosorbent assay.The Hamilton Depression Scale(HAMD⁃17)and Hamilton Anxiety Scale(HAMA)were used to evaluate the depressive symptoms.The receiver operating characteristic curve(ROC)was used to analyze the diagnostic value of serum SP,Glu,BDNF,and clinical symptom scores for bipolar depression.Results There was no significant difference in gender ratio,age,and educational age between patients with bipolar depression,depression and the control group,and there was no significant difference in the course of disease and age at onset between patients with bipolar depression and depression(P>0.05).The serum SP,Glu,BDNF levels and HAMD and HAMA scores of patients with bipolar depression and depression were higher than those of healthy controls(P<0.05).The levels of serum SP,BDNF,HAMD and HAMA in the bipolar depression group were significantly lower than those in the depression group(P<0.05).After ROC analysis,After ROC analysis,the AUC value of the combined detection of serum SP,BDNF and symptom scores HAMD and HAMA was 0.906,which was better than the single detection(P<0.05).The diagnostic AUC,sensitivity and specificity are 0.831,92.9%and 73.0%,respectively(P<0.05).Conclusion The serum indicators of SP,Glu,and BDNF of depression in bipolar disorder are abnormal,and the degree of disorder of serum indicators and symptoms of anxiety and depression in patients with depression with bipolar dis

关 键 词：抑郁症 双相抑郁症 P物质 脑源性神经营养因子 

分 类 号：R749.4[医药卫生—神经病学与精神病学]