Prdx1、Prdx3蛋白在卵巢浆液性肿瘤中的表达及临床意义  

Expression and clinical significance of Prdx1 and Prdx3 proteins in ovarian serous tumors

作　　者：李淑红[1] 薛惠英[1] 刘现红[1] LI Shuhong;XUE Huiying;LIU Xianhong(Department of Gynecology,Anyang People’s Hospital,Anyang,Henan,China,455000)

机构地区：[1]安阳市人民医院妇科,河南安阳455000

出　　处：《分子诊断与治疗杂志》2022年第5期857-860,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省科技攻关联合共建项目(2018021012)。

摘　　要：目的探讨过氧化物氧化还原酶蛋白1(Prdx1)、过氧化物氧化还原酶蛋白3(Prdx3)蛋白在卵巢浆液性肿瘤中的表达情况及其与临床病理特征的关系。方法选取安阳市人民医院2018年7月至2021年5月确诊的卵巢浆液性腺癌患者64例、交界性浆液性肿瘤56例、浆液性囊腺瘤80例为研究对象,通过免疫组织化学(IHC)和蛋白质印迹法(WB)检测三组标本中的Prdx1、Prdx3蛋白表达情况并分析其与卵巢浆液性腺癌患者临床病理学特征的关系。结果卵巢浆液性腺癌的Prdx1、Prdx3蛋白表达阳性率及相对表达量高于交界性卵巢浆液性肿瘤和浆液性囊腺瘤,差异有统计学意义(P<0.05),交界性卵巢浆液性肿瘤的Prdx1、Prdx3蛋白表达阳性率及相对表达量高于浆液性囊腺瘤,差异有统计学意义(P<0.05)。不同临床分期及有无淋巴结转移的浆液性腺癌患者Prdx1、Prdx3蛋白阳性表达率差异有统计学意义(P<0.05)。结论Prdx1、Prdx3蛋白在卵巢浆液性腺癌中呈现高表达,并且与其发生及进展密切相关,对于卵巢浆液性腺癌的诊疗具有一定的临床价值。Objective To investigate the expression of peroxidoreductase protein 1(Prdx1)and peroxidoreductase protein 3(Prdx3)in serous ovarian cancer tissues and their correlation with clinical features.Methods A total of 64 cases of ovarian serous adenocarcinoma,56 cases of borderline serous tumor and 80cases of serous cystadenoma diagnosed in Anyang People’s Hospital from July 2018 to May 2021 were selected as the research objects. Prdx1 and Prdx3 protein expressions in the three groups were assessed by Immunohistochemistry(IHC) and Western blot(WB), their relationship with the clinicopathological characteristics of ovarian serous adenocarcinoma patients was analyzed. Results The positive and relative expression levels of Prdx1 and Prdx3 proteins in serous ovarian adenocarcinoma were higher than those in serous ovarian tumor and serous cystadenoma(P < 0.05),and the positive rate and relative expression levels of Prdx1 and Prdx3 proteins in serous ovarian tumor were higher than those in serous cystadenoma(P<0.05).There were significant differences in the positive expression rates of Prdx1 and Prdx3 proteins between patients with serous adenocarcinoma with different clinical stages and with or without lymph node metastasis(P<0.05).Conclusion Prdx1 and Prdx3 proteins are highly expressed in ovarian serous adenocarcinoma,and are closely related to their occurrence and progression,which has certain clinical value for the diagnosis and treatment of ovarian serous adenocarcinoma.

关 键 词：过氧化物氧化还原酶蛋白1 过氧化物氧化还原酶蛋白3 卵巢癌 

分 类 号：R737.31[医药卫生—肿瘤]