非酒精性脂肪性肝病进展中cGAS/STING信号通路激活及其免疫学作用  

Activation of cGAS/STING signaling pathway and its immunological role in the progression of nonalcoholic fatty liver disease

作　　者：沙春秀 居林玲 周平[1] 姚登福[2] 姚敏[1] Sha Chunxiu;Ju Lin ling;Zhou Ping;Yao Dengfu;Yao Min(Department of Immunology,Medical School of Nantong University,Nantong 226001,China;Research Center of Clinical Medicine,Affiliated Hospital of Nantong University,Nantong 226001,China)

机构地区：[1]南通大学医学免疫学系,南通226001 [2]南通大学附属医院临床医学研究中心,南通226001

出　　处：《中华肝脏病杂志》2022年第5期564-568,共5页Chinese Journal of Hepatology

基　　金：国家自然科学基金(31872738);南通市重点专项(MS12020021)。

摘　　要：非酒精性脂肪性肝病仍是当今最主要的慢性肝病。细胞DNA传感器环磷酸鸟-腺苷合成酶(cGAS)通过催化合成环磷酸鸟苷,激活干扰素基因刺激因子(STING),释放以I型干扰素为代表的细胞因子引发免疫反应。外源或内源DNA为cGAS配体激活cGAS-STING信号通路,在肝炎、非酒精性脂肪肝疾病、肝癌等疾病中发挥作用,通过自噬和代谢等机制影响肝病进展。现综述非酒精性脂肪肝疾病进展中cGAS-STING通路激活及其分子免疫学作用。Today,nonalcoholic fatty liver disease remains the most dominant chronic liver disease.Cyclic guanosine monophosphate-adenosine monosphosphate synthase(cGAS)is a cytosolic DNA sensor that catalyzes the synthesis of cyclic guanosine monophosphate,activates stimulator of interferon genes(STING),and releases type-I interferon cytokines to trigger immune responses.Exogenous or endogenous DNA acts as a cGAS ligand to activate the cGAS-STING signaling pathway,which plays a role in hepatitis,nonalcoholic fatty liver disease,liver cancer and other diseases,and affects liver disease progression and metabolism through mechanisms such as autophagy.This article reviews the activation of cGAS-STING pathway and its molecular immunological role in nonalcoholic fatty liver disease progression.

关 键 词：非酒精性脂肪性肝病 cGAS/STING通路 脂代谢异常 慢性肝病 

分 类 号：R575.5[医药卫生—消化系统]