脑源性神经营养因子与神经炎症在神经退行性疾病中的作用研究进展  

Progress in research on the role of brain-derived neurotrophic factor and neuroinflammation in neurodegenerative diseases

作　　者：邢维昊 张婕[1] 巫晓宇 刘凤 熊静[1] XING Weihao;ZHANG Jie;WU Xiaoyu;LIU Feng;XIONG Jing(Department of Neurology,the Second Affiliated Hospital of Kunming Medical University,Yunnan,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院神经内科,云南昆明650101 [2]昆明医科大学

出　　处：《中国医药科学》2022年第10期21-24,共4页China Medicine And Pharmacy

基　　金：云南省卫生和计划生育委员会医学学科带头人培养计划(D-2017028);云南省教育厅科学研究基金项目(220J0186);云南省昆明医科大学研究生创新基金项目(2021S221)。

摘　　要：证据表明,脑源性神经营养因子前体(proBDNF)和成熟脑源性神经营养因子(mBDNF)通过维持神经元存活、可塑性和调节神经递质,在阿尔茨海默病(AD)、帕金森病(PD)等神经退行性疾病的病理生理机制中发挥重要作用。慢性炎症反应是神经退行性疾病的关键性驱动因素,影响多个脑源性神经营养因子(BDNF)相关的信号通路。现对proBDNF、mBDNF和神经炎症在神经退行性疾病中的作用机制及研究进展进行综述,了解神经炎症与BDNF在神经退行性疾病的相互作用,有助于制订新的治疗策略。There is considerable evidence that pro-brain-derived neurotrophic factor(proBDNF)and mature brain-derived neurotrophic factor(mBDNF)play important roles in the pathophysiology of neurodegenerative diseases such as Alzheimer’s disease(AD)and Parkinson’s disease(PD)by regulating neurotransmitters,and maintaining neuronal survival and plasticity.Chronic inflammatory res ponse is a key driver of neurodegenerative diseases,affecting multiple BDNF-related signaling pathways.Here we review the mechanisms and research progress of proBDNF,mBDNF and neuroinflammation in neurodegenerative diseases.Understanding the interaction between neuroinflammation and BDNF in neurodegenerative diseases is helpful for developing new therapeutic strategies.

关 键 词：脑源性神经营养因子 神经炎症 神经退行性疾病 阿尔茨海默病 帕金森病 

分 类 号：R-1[医药卫生] R741