基于“肝肾同源”理论探讨OPG/RANKL/RANK信号系统在骨转移癌痛中的调控机制  

OPG/RANKL/RANK Signaling Regulation Mechanism of Cancer-induced Bone Pain Based on"the Same Source of Liver and Kidney"Theory

作　　者：李玲[1] 李菁 LI Ling;LI Jing(Shuguang Hospital Affiliated to Shanghai University of TCM,Shanghai 201203,China;The First Hospital of Hunan University of Chinese Medicine)

机构地区：[1]上海中医药大学附属曙光医院,上海201203 [2]湖南中医药大学第一附属医院

出　　处：《西部中医药》2022年第6期149-152,共4页Western Journal of Traditional Chinese Medicine

基　　金：2018年度湖南中医药大学校级科研基金项目(2018XJJJ54)。

摘　　要：从肝肾同源理论的应用出发,结合骨保护素(osteoprotegerin,OPG)/核因子受体活化因子NF-κB配体(receptor activator of NF-κB ligand,RANKL)/NF-κB受体活化因子(receptor activator for NF-κB,RANK)信号系统在骨代谢中的调控机制,阐释肝肾同源理论应用于临床的客观分子生物学依据,更好地指导临床。Objective molecular biological evidence of applying"the same source of liver and kidney"is explained on the foundation of the application of the theory,combined with the regulatory mechanism of OPG/RANKL/RANK signaling system in bone metabolism,in order to better guide clinical prevention and treatment of bone metastasis cancer pain.

关 键 词：骨转移癌痛 肝肾同源 OPG/RANKL/RANK信号系统 

分 类 号：R733.3[医药卫生—肿瘤]