复方翅果油的毒理学初步研究  

Preliminary toxicological study of compound Elaeagnus mollis seed oil

作　　者：唐慧[1] 王默[2] 李伟[3] 张静[1] 周雯[1] 程东[1] TANG Hui;WANG Mo;LI Wei;ZHANG Jing;ZHOU Wen;CHENG Dong(Shandong Center for Disease Control and Prevention,Jinan 250014,China;Shandong Provincial Hospital,Jinan 250021,China;Huaiyin District Center for Disease Control and Prevention,,Jinan 250022,China)

机构地区：[1]山东省疾病预防控制中心,济南250014 [2]山东省立医院,济南250021 [3]济南市槐荫区疾病预防控制中心,济南250022

出　　处：《中国油脂》2022年第4期92-97,101,共7页China Oils and Fats

摘　　要：旨在对复方翅果油(翅果油+葡萄籽油)的毒理学安全性进行初步评估。采用最大耐受剂量(MTD)法观察复方翅果油的急性毒性,选择Ames试验、骨髓嗜多染红细胞微核试验、小鼠精子畸形试验观察复方翅果油的遗传毒性,通过亚急性毒性试验观察复方翅果油的亚急性毒性。结果表明:复方翅果油对雄、雌小鼠的MTD均大于20.0 g/kg;遗传毒性试验结果为阴性;各剂量组未观察到有明显的亚急性毒性。上述结果说明复方翅果油属无毒级,无明显遗传毒性和亚急性毒性。To study the safety of compound Elaeagnus mollis seed oil(blend oil of Elaeagnus mollis seed oil and grape seed oil),maximum tolerated dose(MTD)was used to observe acute toxicity of compound Elaeagnus mollis seed oil,and Ames test,bone marrow polychromatic erythrocyte micronucleus test and mice sperm abnormality test were used to study the inherent toxicity,and the sub-acute toxicity test was used to study the sub-acute toxicity of compound Elaeagnus mollis seed oil.The results showed that the oral MTD of compound Elaeagnus mollis seed oil in male and female mice was above 20.0 g/kg.The result of inherent toxicity test was negative.There was no evident sub-acute toxicity in each dose group.So compound Elaeagnus mollis seed oil belonged to non-toxic grade and had no significant inherent toxicity or sub-acute toxicity.

关 键 词：复方翅果油 急性毒性 遗传毒性 亚急性毒性 

分 类 号：TS225.1[轻工技术与工程—粮食、油脂及植物蛋白工程] TS201.6[轻工技术与工程—食品科学与工程]