超声测量视神经鞘直径评估猪急性颅内高压合并脑疝的研究  

Evaluation of Acute Intracranial Hypertension with Cerebral Hernia in Swine by Ultrasonic Measurement of Optic Sheath Diameter

作　　者：吴红月 朱晓玲 牟思瞳 李小蝶 唐运宽 唐华民 WU Hong-yue;ZHU Xiao-ling;MOU Si-tong;LI Xiao-die;TANG Yun-kuan;TANG Hua-min(The Second Clinical College of Guangxi Medical University,Nanning City,Guangxi Zhuang Autonomous Region,530021,China;Emergency Department,the Second Affiliated Hospital of Guangxi Medical University,Nanning City,Guangxi Zhuang Autonomous Region,530007,China;Guangxi International Zhuang Medical Hospital Affiliated to Guangxi University of Traditional Chinese Medicine,Nanning City,Guangxi Zhuang Autonomous Region,530001,China;Emergency and First Aid Joint Center,Research Laboratory of Zhuang&Yao Medicine,Guangxi International Zhuang Medical Hospital,Nanning City,Guangxi Zhuang Autonomous Region,530201,China)

机构地区：[1]广西医科大学第二临床医学院,广西南宁530021 [2]广西医科大学第二附属医院急诊科,广西南宁530007 [3]广西中医药大学附属广西国际壮医医院,广西南宁530001 [4]广西国际壮医医院急诊急救联动中心<创伤中心>/壮瑶医药研究实验室,广西南宁530201

出　　处：《蛇志》2022年第2期163-166,共4页Journal of Snake

基　　金：国家自然科学基金资助项目(项目名称:MRI对颅内穿刺急救STBI合并脑疝的机制研究;项目编号:81660327);广西国际壮医医院引进人才科研启动基金;广西医疗卫生重点培育学科(急诊医学)2021。

摘　　要：目的探讨超声测量视神经鞘直径(ONSD)与急性颅内高压合并脑疝猪动物模型颅内压(ICP)变化的关系。方法选择普通健康广西巴马小型猪8头,建立急性颅内高压合并脑疝的猪模型。于脑室内置入ICP探测条监测ICP变化,经颅多普勒超声测量实验猪造模前后ONSD,并比较造模前后猪ICP平均值与双眼ONSD,分析ICP与ONSD的相关性。结果建立急性颅内高压合并脑疝模型的实验猪,在造模前后的ICP平均值比较,差异有统计学意义(P<0.001);双眼ONSD在造模前后平均值比较,差异具有统计学意义(P<0.001)。Pearson相关性分析显示,ONSD与ICP呈正相关(r=0.963,P<0.001)。结论床旁超声可快速检测实验猪ONSD变化,对猪急性颅内高压合并脑疝模型ICP变化的评估有重要意义,为超声评估ICP变化的临床推广提供了基础研究依据。Objective To investigate the relationship between the diameter of optic nerve sheath measured by ultrasound and the changes of intracranial pressure in swine model of acute intracranial hypertension complicated with cerebral hernia.Methods Eight healthy Guangxi Bama mini swines were selected to establish the model of acute intracranial hypertension complicated with cerebral hernia,and the changes of intracranial pressure were monitored.The diameter of optic nerve sheath before and after modeling was measured by transcranial Doppler ultrasound,and the relationship between them was discussed.Results The models of acute intracranial hypertension complicated with cerebral hernia were established by all 8 experimental animals.There was significant difference in the average intracranial pressure before and after modeling(P<0.001).There was significant difference in the diameter of optic nerve sheath before and after modeling(P<0.001).Pearson correlation analysis showed that the diameter of optic nerve sheath was positively correlated with intracranial pressure(r=0.963,P<0.001).Conclusion Bedside ultrasound can quickly detect the changes of optic nerve sheath diameter,which is of great significance for the evaluation of intracranial pressure changes in swines with acute intracranial hypertension complicated with cerebral hernia model,and provides a basic research basis for ultrasound to evaluate the changes of intracranial pressure.

关 键 词：猪 创伤性脑损伤 颅内高压 ONSD 床旁超声 

分 类 号：R-332[医药卫生]