Analgesic Effects of Two Types of Spinal Manipulation in Acute Lumbar Radiculopathy Model Rats  

作　　者：HAN Lei ZHAO Ping HAN Xue WEI Jie WANG Fei LI Yi GUO Guang-jin 

机构地区：[1]Spine Center of Manipulative Orthopedics,Air Force Medical Center,Beijing,100142,China [2]Department of Bone and Joint Imaging Diagnosis,Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing,100102,China

出　　处：《Chinese Journal of Integrative Medicine》2022年第6期518-523,共6页中国结合医学杂志（英文版）

基　　金：Supported by Youth Project of National Natural Science Foundation of China(No.81503602)。

摘　　要：Objective:To compare the analgesic effects of two types of spinal manipulation(SM)in acute lumbar radiculopathy(ALR)model rats induced by self-transplantation of autologous nucleus pulposus(ANP),and clarify the therapeutic mechanism.Methods:Totally 108 male Sprague-Dawley rats were randomly divided into 6 groups by a random number table(18 rats in each group),including a blank group with no interference,a sham operation group with a surgery by making a local soft tissue incision on the left side of L5-6 vertebral segment,a model group with ALR of L5 extraforaminal nerve by ANP self-transplantation without other interference,a sham manipulation(SMA)group with simulating physical rotation,as well as a mobilization(MOB)group with simulating low-velocity and variable-amplitudle rotation and a manipulation(MAN)group with simulating high-velocity and low-amplitude rotation.The interventions in SMA,MOB,and MAN groups started 1 day after modeling followed by another 5 treatments at days 3,5,8,10 and 12.Rats in the other3 groups did not receive any special intervention.Behavioral pain tests of 50%mechanical pain withdrawal threshold(50%PWT)and paw withdrawal latency(PWL)were conducted 1 day before operation followed by another 10 tests on days 1-7,10,12 and 14.Immunohistochemical expression of nitric oxide synthase(NOS)was investigated on days 5 and 12 after operation.Results:After 3 experimental SM interventions,50%PWT and PWL were higher in the MAN group than the SMA group on days 6 and 7,and higher on days 10,12 and14 postoperatively(P<0.05 or P<0.01),while the same indices were significantly higher in the MOB group than MAN group on days 1-4(P<0.05 or P<0.01).The expression of NOS was lower in the MAN and MOB groups than SMA group on day 12 postoperatively(P<0.01).Conclusions:Both manipulation and mobilization produced better results than sham interference in relieving pain by reducing neuroinflammation possibly.At the early period,compared with manipulation,mobilization presented less sensitive response to pain until

关 键 词：spinal manipulation RADICULOPATHY ANTI-INFLAMMATION ANALGESIA 

分 类 号：R681.55[医药卫生—骨科学]