Protective Roles of Shilajit in Modulating Resistin,Adiponectin,and Cytokines in Rats with Non-alcoholic Fatty Liver Disease  

作　　者：Baran Ghezelbash Nader Shahrokhi Mohammad Khaksari Gholamreza Asadikaram Maryam Shahrokhi Sara Shirazpour 

机构地区：[1]Physiology Research Center,Kerman University of Medical Sciences,Kerman,7616914115,Iran [2]Endocrinology,and Metabolism Research Center,Kerman University of Medical Sciences,Kerman,7616914115,Iran [3]Department of Biochemistry,School of Medicine,Kerman University of Medical Sciences,Kerman,7616914115,Iran [4]Department of Medical Science,School of Dentistry,Shiraz University of Medical Sciences,Shiraz,713414336,Iran [5]Department of Physiology and Pharmacology,Faculty of Medicine,Kerman University of Medical Sciences,Kerman,7616914115,Iran

出　　处：《Chinese Journal of Integrative Medicine》2022年第6期531-537,共7页中国结合医学杂志（英文版）

基　　金：Supported by Department of Physiology and Pharmacology,Kerman University of Medical Sciences,Kerman,Iran。

摘　　要：Objective:To evaluate the effect of Shilajit,a medicine of Ayurveda,on the serum changes in cytokines and adipokines caused by non-alcoholic fatty liver disease(NAFLD).Methods:After establishing fatty liver models by feeding a high-fat diet(HFD)for 12 weeks,35 Wistar male rats were randomly divided into5 groups,including control(standard diet),Veh(HFD+vehicle),high-dose Shilajit[H-Sh,HFD+250 mg/(kg·d)Shilajit],low-dose Shilajit[L-Sh,HFD+150 mg/(kg·d)Shilajit],and pioglitazone[HFD+10 mg/(kg·d)pioglitazone]groups,7 rats in each group.After 2-week of gavage administration,serum levels of glucose,insulin,interleukin1 beta(IL-1β),IL-6,IL-10,tumor necrosis factor-alpha(TNF-α),adiponectin,and resistin were measured,and insulin resistance index(HOMA-IR)was calculated.Results:After NAFLD induction,the serum level of IL-10 significantly increased and serum IL-1β,TNF-αlevels significantly decreased by injection of both doses of Shilajit and pioglitazone(P<0.05).Increases in serum glucose level and homeostasis model of HOMA-IR were reduced by L-Sh and H-Sh treatment in NAFLD rats(P<0.05).Both doses of Shilajit increased adiponectin and decreased serum resistin levels(P<0.05).Conclusion:The probable protective role of Shilajit in NAFLD model rats may be via modulating the serum levels of IL-1β,TNF-α,IL-10,adipokine and resistin,and reducing of HOMA-IR.

关 键 词：non-alcoholic fatty liver disease SHILAJIT ADIPOKINES CYTOKINES glucose INSULIN dietary supplement Ayurvedic medicine 

分 类 号：R965[医药卫生—药理学]