miR-196在非小细胞肺癌发生、发展及诊断中的研究进展  

Progress of miR-196 in the development and diagnosis of non-small cell lung cancer

作　　者：吴斌[1] 郑敏[1] 徐烨[1] 郭清奎[1] 钱文良[1] 朱辰[1] 王宁 赵闻 Wu Bin;Zheng Min;Xu Ye;Guo Qingkui;Qian Wenliang;Zhu Chen;Wang Ning;Zhao Wen(Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200336,China)

机构地区：[1]上海交通大学医学院附属同仁医院,上海200336

出　　处：《国际外科学杂志》2022年第4期279-283,共5页International Journal of Surgery

基　　金：上海市长宁区卫健委长宁区医学名专科(YXMZK008)。

摘　　要：微小核糖核酸(miRNAs)是一类广泛存在的内源性单链非编码小RNA,在组织与体液中均稳定表达,通过与信使RNA(mRNA)序列互补来降解靶mRNA,阻断蛋白编码基因的表达,在转录后调控和不同的生物学过程中发挥着关键作用。近年来越来越多的研究表明,miRNAs与肿瘤的发生、发展密切相关。其中,微小核糖核酸-196(miR-196)作为miRNAs家族中的成员之一,在非小细胞肺癌患者的血清、组织及细胞中异常表达,参与非小细胞肺癌的发生、发展,在肿瘤细胞的增殖、侵袭及转移等多种生物学过程中起着重要的调控作用,为非小细胞肺癌的早期筛查提供诊断依据。本文就miR-196在非小细胞肺癌发生、发展及诊断中的研究进展进行综述。Microribonucleic acid(miRNAs)is a widely existing endogenous single-stranded non-coding small RNA,which is stably expressed in tissues and body fluids.By complementing messenger RNA(mRNA)sequences,miRNAs degrade target mRNA and block the expression of protein-coding genes,playing a key role in post-transcriptional regulation and different biological processes.In recent years,more and more studies have shown that miRNAs are closely related to the occurrence and development of tumors.Among them,as a member of the miRNAs family,microribonucleic acid-196(miR-196)is abnormally expressed in the serum,tissues and cells of patients with non-small cell lung cancer,participating in the occurrence and development of non-small cell lung cancer and playing an important regulatory role in various biological processes such as proliferation,invasion and metastasis,providing diagnostic evidence for early screening of non-small cell lung cancer.This paper reviews the progress of miR-196 in the development and diagnosis of non-small cell lung cancer.

关 键 词：肺肿瘤 非小细胞肺癌 诊断 微小核糖核酸-196 发展 

分 类 号：R734.2[医药卫生—肿瘤]