淫羊藿黄酮苷类化合物生物转化的研究进展  

Research progress on the biotransformation of flavonoid glycosides in Epimedii Folium

作　　者：张宇航 陈旺 冯自立[1,2] 袁洪超[3] 高小林 王翠萍 ZHANG Yuhang;CHEN Wang;FENG Zili;YUAN Hongchao;GAO Xiaolin;WANG Cuiping(School of Bioscience and Engineering,Shaanxi University of Technology,Shaanxi Hanzhong 723000,China;Shaanxi Provincial Key Lab of Bio-resource,Shaanxi University of Technology,Shaanxi Hanzhong 723000,China;Shaanxi Jinhuifang Traditional Chinese Medicine Technology Company,Shaanxi Hanzhong 723000,China;Shaanxi Tianrangu Biotechnology Co.,Ltd.,Shaanxi Hanzhong 723000,China;Shaanxi Tiangu Pharmaceutical Co.,Ltd.,Shaanxi Hanzhong 723000,China)

机构地区：[1]陕西理工大学生物科学与工程学院,陕西汉中723000 [2]陕西理工大学陕西省资源生物重点实验室,陕西汉中723000 [3]陕西金慧方中药科技有限公司,陕西汉中723000 [4]陕西天然谷生物科技股份有限公司,陕西汉中723000 [5]陕西天谷药业有限公司,陕西汉中723000

出　　处：《中国药房》2022年第12期1525-1529,共5页China Pharmacy

基　　金：陕西省科技厅研发计划项目(No.2020LSFP2-34);陕西省重点研发计划项目(No.2022SF-406);陕西省自然科学基础研究计划项目(No.2022JM-576)。

摘　　要：淫羊藿黄酮苷类化合物是淫羊藿及其同属植物的主要活性成分,根据所含糖基数目的不同分为多糖苷类化合物和低糖苷类化合物。淫羊藿多糖苷类化合物经生物转化后可生成低糖苷类化合物,后者在抗肿瘤、补肾阳、抗骨质疏松等方面的药理活性强于多糖苷类化合物。本文综述了淫羊藿黄酮苷类化合物生物转化技术的研究进展,发现通过除去糖基获得低糖苷类化合物是淫羊藿黄酮苷类化合物的主要生物转化途径;相关方法以酶水解法和微生物转化法为主,还包括植物细胞转化法、酸水解法和合成法。Flavonoid glycosides are the main active constituents of Epimedii Folium and its related plants. They can be divided into polyglycosides and low glycosides according to the number of glycosyl group. The polyglycosides of Epimedii Folium can be transformed into low glycosides after biotransformation;pharmacological activities of low glycosides in anti-tumor,tonifying kidney yang and anti-osteoporosis are stronger than those of polyglycosides. In this paper, the research progress about biotransformation technology of flavonoid glycosides of Epimedii Folium was reviewed. It was found that the main biotransformation pathway of flavonoid glycosides of Epimedii Folium was to obtain low glycosides by removing glycosyl group;related methods were mainly enzymatic hydrolysis and microbial transformation,and also included plant cell transformation,acid hydrolysis method and synthesis method.

关 键 词：淫羊藿 黄酮苷类化合物 低糖苷类化合物 生物转化 

分 类 号：R914[医药卫生—药物化学]