炎症性肠病相关肠道菌群失调的机制及治疗的研究进展  

Research progress on mechanism and treatment of inflammatory bowel disease-related intestinal flora imbalance

作　　者：刘靖伟 殷云勤[2] LIU Jing-Wei;YIN Yun-Qin(First Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China;Department of Gastroenterology,First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院,太原030001 [2]山西医科大学第一医院消化科,太原030001

出　　处：《中华老年多器官疾病杂志》2022年第5期397-400,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：炎症性肠病(IBD)是一种慢性反复发作的非特异性肠道炎症性疾病,其发病与多种因素相关。尽管IBD的病因尚不清楚,但肠道菌群被认为是IBD发病机制中的一个重要因素。肠道菌群对肠道免疫系统的发育和激活具有重要作用,而肠道菌群的变化可能诱发或加重IBD,但其中机制尚未完全明确,且研究发现,基于调节肠道菌群的方案对IBD的治疗具有一定的积极作用。本文就目前肠道菌群失调引起IBD的机制及相关治疗的研究进展作一综述。Inflammatory bowel disease(IBD)is a chronic and recurrent non-specific intestinal inflammatory disease,and its pathogenesis is related to many factors.Although the etiology of IBD remains unclear,intestinal flora is considered to be an important factor in the pathogenesis of IBD.Intestinal flora has been proven to play an important role in the development and activation of the intestinal immune system.Dysbiosis of the gut microbiota may induce or aggravate IBD,but the underlying mechanism is not yet fully illustrated.Evidence shows that treatment regimens based on regulation of intestinal flora have a certain positive effect on IBD.In this article,we review the recent researches on dysbiosis-implicated IBD and related treatments.

关 键 词：肠道菌群 菌群失调 炎症性肠病 益生菌 粪菌移植 

分 类 号：R57[医药卫生—消化系统]