消栓肠溶胶囊联合多奈哌齐治疗血管性痴呆的疗效及对患者血清细胞因子和氧化应激的影响  

Efficacy of Xiaoshuan Changrong Capsules combined with donepezil hydrochloride in the treatment of patients with vascular dementia and their effects on serum cytokines and oxidative stress

作　　者：胡晨玲[1] 缪群[2] 林明霞[1] 罗伏钢[3] Hu Chenling;Miao Qun;Lin Mingxia;Luo Fugang(The Fourth Ward for Older Adults,Hangzhou Seventh People's Hospital,Hangzhou 310013,Zhejiang Province,China;Department of Prevention and Health Care,Hangzhou First People's Hospital,Hangzhou 310003,Zhejiang Province,China;Department of Intensive Care Unit,Hangzhou Seventh People's Hospital,Hangzhou 310013,Zhejiang Province,China)

机构地区：[1]杭州市第七人民医院老年四病区,杭州310013 [2]杭州市第一人民医院预防保健科,杭州310013 [3]杭州310003,杭州市第七人民医院重症医学科,杭州310013

出　　处：《中国基层医药》2022年第5期706-710,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省杭州市科技发展计划项目(20150633B10)。

摘　　要：目的探讨消栓肠溶胶囊联合盐酸多奈哌齐治疗血管性痴呆的疗效及对患者血清细胞因子和氧化应激的影响。方法选取杭州市第七人民医院2019年1月至2021年1月收治的血管性痴呆患者102例为观察对象, 采用随机数字表法分为观察组与对照组, 每组51例。对照组患者口服盐酸多奈哌齐治疗, 观察组在盐酸多奈哌齐基础上口服消栓肠溶胶囊。两组治疗疗程12周。比较两组治疗12周疗效, 治疗前后临床痴呆量表(CDR)评分和简易智能状态量表(MMSE)评分、细胞因子[白细胞介素6(IL-6)、胰岛素样生长因子1(IGF-1)、肿瘤坏死因子α(TNF-α)]和氧化应激[超氧化物歧化酶(SOD)和丙二醛(MDA)]水平变化。结果观察组患者治疗总有效率[90.20%(46/51)]高于对照组[70.59%(36/51)](χ^(2)=6.22, P < 0.05);观察组患者治疗12周CDR评分[(1.34±0.27)分]低于对照组[(1.89±0.31)分], MMSE评分[(25.45±1.98)分]高于对照组[(22.32±2.10)分](t=9.55、7.74, 均P < 0.05);观察组患者治疗12周IL-6[(31.28±7.35)ng/L]、IGF-1[(0.34±0.08)ng/L]和TNF-α[(9.46±2.27)ng/L]均低于对照组[(46.43±6.28)ng/L、(0.48±0.07)ng/L、(20.98±3.56)ng/L](t=11.19、9.40、19.48, 均P < 0.05);观察组患者治疗12周SOD[(98.91±7.25)U/L]高于对照组[(86.59±5.63)U/L], MDA[(3.25±0.50)mmol/L]低于对照组[(4.81±0.35)mmol/L](t=9.58、18.25, 均P < 0.05)。结论消栓肠溶胶囊联合盐酸多奈哌齐治疗血管性痴呆患者疗效良好, 可减轻细胞炎性反应, 改善氧化应激反应, 具备显著创新性和科学性。Objective To investigate the efficacy of Xiaoshuan Changrong Capsules combined with donepezil hydrochloride in the treatment of patients with vascular dementia and their effects on serum cytokines and oxidative stress.Methods A total of 102 patients with vascular dementia who received treatment in Hangzhou Seventh People's Hospital,China between January 2019 and January 2021 were included in this study.They were randomly divided into control and observation groups,with 51 patients per group.The control group was treated by oral donepezil hydrochloride.The observation group was given oral Xiaoshuan Changrong Capsules combined with oral donepezil hydrochloride.All patients were treated for 12 weeks.Efficacy was compared between the two groups.The Clinical Dementia Rating score,the Mini-Mental State Examination score,and serum levels of interleukin 6,insulin-like growth factor-1,tumor necrosis factor-α,superoxide dismutase and malondialdehyde were compared between before and after treatment.Results Total response rate in the observation group was significantly higher than that in the control group[90.20%(46/51)vs.70.59%(36/51),χ^(2)=6.22,P<0.05].At 12 weeks after treatment,the Clinical Dementia Rating score in the observation group was significantly lower than that in the control group[(1.34±0.27)points vs.(1.89±0.31)points,t=9.55,P<0.05].At 12 weeks after treatment,the Mini-Mental State Examination score in the observation group was significantly higher than that in the control group[(25.45±1.98)points vs.(22.32±2.10)points,t=7.74,P<0.05].At 12 weeks after treatment,interleukin-6,insulin-like growth factor-1,and tumor necrosis factor-αlevels in the observation group were(31.28±7.35)ng/L,(0.34±0.08)ng/L and(9.46±2.27)ng/L,respectively,which were significantly lower than those in the control group[(46.43±6.28)ng/L,(0.48±0.07)ng/L,(20.98±3.56)ng/L,t=11.19,9.40,19.48,all P<0.05].At 12 weeks after treatment,superoxide dismutase in the observation group was significantly higher than that in the control group

关 键 词：痴呆 血管性 神经元 细胞因子类 氧化性应激 炎性反应 胆碱酯酶抑制剂 中药 

分 类 号：R749.13[医药卫生—神经病学与精神病学]