不同营养干预手段对鼻咽癌患者生活质量及治疗中断率的影响  

Effects of Different Nutritional Interventions on the Quality of Life and Treatment Interruption Rate of Patients with Nasopharyngeal Carcinoma

作　　者：杜亚娟[1] 林慧娟[1] 张凤萍 DU Yajuan;LIN Huijuan;ZHANG Fengping(The First Affiliated Hospital of Xiamen University,Xiamen 361003,China;不详)

机构地区：[1]厦门大学附属第一医院,福建厦门361003

出　　处：《中外医学研究》2022年第14期150-154,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：厦门大学附属第一医院厦门市肿瘤医院青年人才科研基金项目(ZLYYB201713)。

摘　　要：目的:探讨不同营养干预手段对鼻咽癌患者生活质量及治疗中断率的影响。方法:回顾性分析2019年12月-2020年12月厦门大学附属第一医院在放疗中存在营养不良的鼻咽癌患者104例,根据患者接受的营养支持方式分为肠内营养支持组(40例)与肠外营养支持组(64例),比较两组患者营养状况、生命质量及治疗中断率。结果:肠内营养支持组在开始放疗后第4~7周PG-SGA评分增加值显著低于肠外营养支持组(P<0.05);肠内营养支持组在放疗后的淋巴细胞绝对值显著高于肠外营养支持组(P<0.05);肠内营养支持组的放疗中断率及两组放疗后血清白蛋白比较差异无统计学意义(P>0.05);放疗后肠外营养支持组的角色功能、社会功能评分高于肠内营养支持组(P<0.05);恶心呕吐、疲倦的评分高于肠内营养支持组(P<0.05)。结论:相对于肠外营养支持,肠内营养支持能有效改善患者营养状况及免疫功能,同时,肠内营养支持组明显减轻患者癌性疲倦、恶心呕吐症状,放疗中营养不良的鼻咽癌患者推荐使用肠内营养支持治疗。Objective:To investigate the effect of different nutritional interventions on the quality of life and treatment interruption rate of NPC patients.Method:A retrospective analysis of 104 NPC patients with malnutrition in radiotherapy at the First Affiliated Hospital of Xiamen University from December 2019 to December 2020.According to the nutritional support mode,the patients were divided into enteral nutrition support group(40 patients)and parenteral nutrition support group(64 patients).The nutritional status,quality of life,and the number of radiotherapy interruptions,during and after radiotherapy were compared in both groups,respectively.Result:The added value of the PG-SGA score in the enteral nutritional support group at 4 to 7 weeks after starting radiotherapy was significantly lower than that in the parenteral nutritional support group(P<0.05).In addition,the absolute value of lymphocytes in the enteral nutritional support group was significantly higher than that in the parenteral nutritional support group(P<0.05).There were no significant differences in the interruption rate of radiotherapy in enteral nutrition support group and serum albumin after radiotherapy between the two groups(P>0.05).After radiotherapy,the role function and social function scores of parenteral nutrition support group were higher than those of enteral nutrition support group(P<0.05).The scores of nausea,vomiting and fatigue were higher than those of enteral nutrition support group(P<0.05).Conclusion:Compared with parenteral nutrition support,enteral nutrition support can effectively improve the nutritional status and immune function of patients.Meanwhile,enteral nutrition support group significantly reduces the symptoms of cancerous fatigue,nausea and vomiting,and enteral nutrition support therapy is recommended for NPC patients with malnutrition in radiotherapy.

关 键 词：鼻咽癌 放疗 营养风险评估 营养干预 生命质量 放疗中断次数 

分 类 号：R739.63[医药卫生—肿瘤]