Changes and Significance of Cytokines in Serum of Rabbits with Acute Pulmonary Embolism  

作　　者：Yulong Liang Jianjing Liang Wenjing Feng Jinghui Mu 

机构地区：[1]General Surgery,Third Hospital of Hebei Medical University,Shijiazhuang,Hebei,050000,China [2]Hebei University,Baoding,Hebei,071000,China

出　　处：《Journal of Integrative Medicine（双语）》2022年第1期8-11,共4页中西医结合杂志（英文）

摘　　要：Objective:To observe the changes of cytokines in serum of rabbits with acute pulmonary embolism,and to provide a scientific basis for clinical treatment of the disease.Methods:The animal models of pulmonary embolism were established in 26 healthy rabbits by autologous thrombus reinfusion and normal saline injection,and the serum levels of cytokines(TNF-α,IL-1β,HGF)in the two groups were monitored by enzyme-linked immunosorbent assay.Results:The expression levels of serum inflamma­tory cytokines(TNF-α,IL-1β)increased in both groups of rabbits within 1-3 hours of the acute stage of embolism,but the expression levels of serum inflammatory cytokines in experimental group of rabbits with pulmonary embolism caused by thrombosis increased more obviously.There was no significant change in serum HGF of rabbits before and after embolization in group B.The serum HGF content of experimental rabbits at 1 h,3 h,12 h,24 h and 48 h after embolization was significantly higher than that before embolization.And in the acute stage of embolism(1-12 hours),it showed a gradual upward trend.Conclusions:The expression level of serum growth factor is different in different acute stages of pulmonary embolism.Detect­ing serum cytokines in rabbits with acute pulmonary embolism is of great reference significance for improving clinical diagnosis.

关 键 词：Acute pulmonary embolism THROMBOSIS Rabbit serum Inflammatory cytokines Hepatocyte factor 

分 类 号：R73[医药卫生—肿瘤]