Short and simple peptide-based pH-sensitive hydrogel for antitumor drug delivery  

作　　者：Jie Li Zhongshi Wang Han Han Zhonghua Xu Shasha Li Ying Zhu Yuejian Chen Liang Ge Yuan Zhang 

机构地区：[1]Department of Orthopedics,Xinqiao Hospital,Army Medical University,Chongqing 400038,China [2]State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China [3]School of Pharmacy,Xinjiang Medical University,Urumqi 830054,China [4]Nanjing aifarui Pharmaceutical Technology Co.,Ltd.,Nanjing 210009,China

出　　处：《Chinese Chemical Letters》2022年第4期1936-1940,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos. 81572978 and 81760638);Special Science and Frontier Technology Research Project of Chongqing(No. cstc2016jcyj A0520);Innovative Technology in Military and Clinical Medicine (No. 2018JSLC0035);Natural Science Foundation of Xinjiang Province (No. 2017D01C200)。

摘　　要：Since self-assembled peptide hydrogels can solve the problems such as low solubility, poor selectivity and serious adverse effects of traditional chemotherapy drugs, they have been widely used as carrier materials for drug delivery. In this study, we developed a novel and injectable drug delivery platform for the antitumor drug doxorubicin(DOX) using a p H-responsive ionic-complementary octapeptide FOE.This octapeptide could self-assemble into stable hydrogel under neutral conditions, while disassemble under the tumor microenvironment. Especially, at p H 5.8, its micromorphology displayed a transition from nanofibers to nanospheres with the change of secondary structure, which enhanced cellular uptake of DOX. In addition, FOE hydrogel serves as a smart drug reservoir by localized injection to achieve sustained drug release and improve antitumor efficacy. This octapeptide opens up new avenues for promoting the clinical translation of anticancer drugs on account of excellent injectable properties and economic benefits of simple and short sequence.

关 键 词：Peptide hydrogel pH Sensitivity ANTITUMOR Drug delivery Targeted therapy 

分 类 号：TQ460.4[化学工程—制药化工] TQ427.26