Visible-light-promoted radical alkylation/cyclization of allylic amide with N-hydroxyphthalimide ester: Synthesis of oxazolines  

作　　者：Zhiyang Yan Bin Sun Panyi Huang Haiyun Zhao Hao Ding Weike Su Can Jin 

机构地区：[1]Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology,Hangzhou 310014,China [2]College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310014,China

出　　处：《Chinese Chemical Letters》2022年第4期1997-2000,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 22078299);Zhejiang Provincial Natural Science Foundation of China (Nos. LY21B060005, LQ20B060007);the College of Pharmaceutical Sciences, Zhejiang University of Technology;Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals for the financial help。

摘　　要：An efficient photocatalytic alkylation/cyclization of allylic amide with N-hydroxyphthalimide ester has been developed. The transformation is taken advantage of alkyl radicals to attack allylic amide with the assist of inexpensive rose bengal as photocatalyst to prepare a series of alkyl substituted oxazolines in moderate to excellent yields. High regioselectivity, operational safety, mild conditions and excellent substrate generality give this protocol broad application prospects.

关 键 词：Photocatalysis OXAZOLINES Allylic amide N-Hydroxyphthalimide ester Alkylation/cyclization Decarboxylation 

分 类 号：O626[理学—有机化学]