非肿块型乳腺癌弹性硬度与预后因素的关系研究  

Correlation between hardness and prognosis of non-mass lesion breast cancer

作　　者：岳民璐 刘森[1] 姜桂艳[1] 杨永雁[1] 武永丽[1] YUE Min-lu;LIU Sen;JIANG Gui-yan;YANG Yong-yan;WU Yong-li(Department of Ultrasound,Affiliated People’s Hospital of Inner Mongolia Medical University,Inner Mongolia Cancer Hospital,Hohhot 010010,China)

机构地区：[1]内蒙古医科大学附属人民医院内蒙古肿瘤医院超声科,内蒙古呼和浩特010010

出　　处：《中国临床医学影像杂志》2022年第6期388-390,395,共4页Journal of China Clinic Medical Imaging

基　　金：内蒙古医科大学青年创新基金项目(YKD2020QNCX041)。

摘　　要：目的:利用剪切波弹性成像探究不同形态类型非肿块型病变(Non-mass lesion,NML)型乳腺癌的弹性硬度与病理学预后指标的关系。方法:收集我院2020年1月—2021年9月符合纳入指标的58例NML恶性乳腺病变患者资料,所有患者均接受超声剪切波弹性成像,并进行穿刺活检或手术,以病理学为金标准,记录各项超声弹性指标、病理免疫组化指标,分析弹性模量与病理学预后因素的关系。结果:Ki-67是否高表达、Her-2是否阳性在弥漫型NML型乳腺癌与局灶型NML型乳腺癌组间存在统计学差异(P<0.05);局灶型NML型乳腺癌病灶Emax值在ER阳性组与阴性组间存在统计学差异(P<0.05),弥漫型NML乳腺癌病灶Emax值在PR阳性组与阴性组间存在统计学差异(P<0.05)。结论:不同形态类型的NML型乳腺癌其病理学预后指标存在差异,Ki-67、Her-2的表达可能对NML型乳腺癌的形态产生影响,而ER、PR阳性可能对NML型乳腺癌硬度造成一定影响。Objective: To investigate the relationship between elastic stiffness and pathological prognosis in different types of non-mass lesion(NML) breast cancer by shear wave elastography. Methods: The data of 58 patients with NML malignant breast lesions who met the inclusion criteria from January 2020 to September 2021 were collected. All patients underwent ultrasonic shear wave elastography and underwent puncture biopsy or operation. Taking pathology as the gold standard, various ultrasonic elastic indexes and pathological immunohistochemical indexes were recorded, and the relationship between elastic modulus and pathological prognostic factors was analyzed. Results: There were significant differences in the high expression of Ki-67 and the positive expression of Her-2 between diffuse NML breast cancer and focal NML breast cancer(P<0.05). The Emax value of focal NML breast cancer was statistically different between the ER positive group and the negative group(P <0.05). There was significant difference in the Emax value of diffuse type NML breast cancer between the PR positive group and the negative group(P<0.05). Conclusion: There are differences in pathological prognosis between different types of NML breast cancer. The expression of Ki-67 and Her-2 may affect the morphology of NML breast cancer, while the positive expression of ER and PR may have some effect on the hardness of NML breast cancer.

关 键 词：乳腺肿瘤 超声检查 多普勒 彩色 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]