Molecular mechanisms of isoflavone puerarin against cardiovascular diseases:What we know and where we go  

作　　者：Weida Qin Jianghong Guo Wenfeng Gou Shaohua Wu Na Guo Yuping Zhao Wenbin Hou 

机构地区：[1]Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Peking Union Medical College&Chinese Academy of Medical Sciences,Tianjin 300192,China [2]Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [3]State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China

出　　处：《Chinese Herbal Medicines》2022年第2期234-243,共10页中草药（英文版）

基　　金：supported by the National Key Research and Development Program of China[Grant No.2017YFC1702901];Fundamental Research Funds for the central public welfare research institutes[Project No.JBGS2021002];China Academy of Chinese Medical Sciences(CACMS)innovation fund[Grant No.CI2021A05031]。

摘　　要：Puerarin(Pue),known as a phytoestrogen,has salient bioactivities and is promising against cardiovascular diseases.This article summarizes the underlying molecular mechanisms of Pue in treating cardiovascular diseases,especially regulating the intracellular signal transduction,influencing ion channels,modulating the expression of micro RNA,and impacting on the autophagy,which are mainly involved in the inflammatory signaling pathways,fatty acid/lipid metabolism,oxidative stress,apoptosis,and the like.The protective effect of Pue against cardiovascular diseases mainly involves attenuating the myocardial injury and decreasing the myocardial fibrosis,improving the myocardial ischemia/reperfusion injury,as well as inhibiting the myocardial hypertrophy and atherosclerosis.The molecular mechanisms of Pue’s cardiovascular protective effects for the first time and comment on the state-of-the-art research methods and principles of Pue’s regulation of small molecules were reviewed,so as to provide the rationale for its basic research and clinical applications.

关 键 词：cardiovascular disease molecular mechanism PUERARIN signaling pathways 

分 类 号：R285[医药卫生—中药学]