Structural-visual functional relationships detected by optical coherence tomography in varying age-cohorts' patients with optic neuritis  

作　　者：Wei Shi Hong-Tao Zhang Hua-Xin Zuo Si-Yuan Li Pan-Pan Zheng Quan-Gang Xu Si-Yu Cai Shi-Hui Wei Li Li Chun—Xia Peng 

机构地区：[1]Department of Ophthalmology,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China [2]Department of Ophthalmology,the Third Medical Center of Chinese PLA General Hospital,Beijing 100039,China [3]Clinical Epidemiology and Evidence-based Medicine,Beijing Children's Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China [4]Department of Ophthalmology,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China

出　　处：《International Journal of Ophthalmology(English edition)》2022年第6期967-974,共8页国际眼科杂志（英文版）

基　　金：Supported by the National High Technology Research and Development Program of China(863 Programme,No.2015AA020511);Clinical Support Foundation of PLA General Hospital,China(No.2016FC-TSYS-I016)。

摘　　要：AIM: To assess the relationships of final best-corrected visual acuity(BCVA) and the optic nerve structural loss in varying age-cohorts of optic neuritis(ON) patients.METHODS: This is a retrospective, cross-sectional study.Totally 130 ON subjects(200 eyes) without ON onset within 6mo were included, who underwent BCVA assessment,peripapillary retinal nerve fibre layer(pRNFL) and macular segmented layers evaluation by optical coherence tomography(OCT).RESULTS: For the 0-18y cohort, the final BCVA(logMAR)was significantly better and less frequent recurrences than adult cohorts(P=0.000). The final BCVA(logMAR) in all age-cohorts of the ON patients had negative and linear correlations to the pRNFL thicknesses and macular retinal ganglion cell layer(mRGCL) volumes, when the pRNFL thicknesses were reduced to the thresholds of 57.2-67.5 μm or 0.691-0.737 mm;in mRGCL volumes, respectively, with the strongest interdependence in the 19-40y cohort. The ON patients from varying age cohorts would be threatened by blindness when their pRNFL thicknesses dropped 36.7-48.3 μm or the mRGCL volumes dropped to 0.495-0.613 mm;.CONCLUSION: The paediatric ON has best prognosis and young adult ON exhibits perfectly linear correlations of final vision and structural loss. The pRNFL and the mRGCL could be potential structural markers to predict the vision prognosis for varying-age ON patients.

关 键 词：optic neuritis age-cohort final visual acuity structural impairment linear correlations 

分 类 号：R774.61[医药卫生—眼科]