肺上皮样血管内皮瘤的临床、CT及病理表现  

The clinical,CT and pathological features of pulmonary epithelioid hemangioendothelioma

作　　者：王永丽[1] 杨帆[1] 文智[1] WANG Yongli;YANG Fan;WEN Zhi(CT Room,the Tumor Hospital Affiliatedto Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院CT室,新疆乌鲁木齐830011

出　　处：《实用放射学杂志》2022年第5期730-733,共4页Journal of Practical Radiology

摘　　要：目的探讨肺上皮样血管内皮瘤(PEH)的临床、CT表现及病理特点。方法回顾性分析12例PEH患者的临床资料、CT图像、组织病理学及免疫组化结果。结果CT特征性表现为双肺多发小结节沿支气管血管束走行分布,形态多不规则,胸膜下结节多见,结节轻度强化或边缘明显强化,合并钙化8例,合并肺小叶间隔增厚8例,侵及胸膜10例。C反应蛋白(CRP)11例升高,神经元特异性烯醇化酶(NSE)4例升高。免疫组化标志物CD31均呈阳性,CD3411例阳性,ERG 8例阳性,FactorⅧ4例阳性,Fli-14例阳性,Ki-67阳性成分占病灶的3%~40%。结论PEH多沿支气管血管束走行分布,常合并钙化,可累及肺间质、胸膜,血管内皮标记物多为阳性。Objective To investigate the clinical,CT and pathological features of pulmonary epithelioid hemangioendothelioma(PEH).Methods The clinical data,CT images,histopathology and immunohistochemical results of 12 patients with PEH were ana lyzed retrospectively.Results CT images were characterized by multiple small nodules distributed along the bronchovascular bundle with irregular morphology in both lungs.Subpleural nodules were common,with slight enhancement or obvious edge enhancement,in addition,there were 8 cases with calcification,8 cases with pulmonary interlobular septal thickening and 10 cases with invasion of pleura.C-reaction protein(CRP)increased in 11 cases,and neuron-specific enolase(NSE)increased in 4 cases.For immunohistochemical markers,CD31 positive were found in all cases,CD34 in 11 cases,ERG in 8 cases,Factor Ⅷ in 4 cases,Fli-1 in 4 cases.Ki-67 positive components accounted for 340%of the lesions.Conclusion PEH is distributed mainly along bronchovascular bundle,often concomitant with calcification,and the pulmonary interstitium and pleura may be involved.Vascular endothelial markers are mostly positive.

关 键 词：上皮样血管内皮瘤 肺肿瘤 计算机体层成像 病理学 

分 类 号：R734.2[医药卫生—肿瘤] R814.42[医药卫生—临床医学] R446.8