晶状体上皮细胞上皮-间质转化的研究进展  

Research progress of epithelial-mesenchymal transition in lens epithelial cells

作　　者：吴睿童 周南[1] 齐艳华[1] Wu Ruitong;Zhou Nan;Qi Yanhua(Department of Ophthalmology,the Second Affiliated Hospital,Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院眼科,150086

出　　处：《国际眼科纵览》2022年第2期123-129,共7页International Review of Ophthalmology

摘　　要：晶状体上皮细胞(lens epithelial cells,LEC)发生上皮-间质转化(epithelial-mesenchymal transition,EMT)是近年来引起关注的白内障术后发生后囊膜混浊的重要机制之一。目前已知多种信号通路涉及晶状体上皮细胞EMT的发生,比如TGF-β/Smad通路、Jagged-1/Notch通路、MAPK/ERK通路、Wnt/β-catenin通路、PI3K/AKT/mTOR通路等,其中最重要的是TGF-β/Smad通路。了解这些信号通路与后发性白内障发病机制的关系可为后发性白内障的预防提供理论基础。(国际眼科纵览,2022,46:123-129)Epithelial-mesenchymal transition(EMT)of lens epithelial cells(LEC)is one of the important mechanisms of posterior capsular opacification(PCO)after cataract operation,which has attracted more and more attention of experts in recent years.Currently various signaling pathways are known to be involved in the occurrence of EMT in lens epithelial cells,such as TGF-β/Smad pathway,Jagged-1/Notch pathway,MAPK/ERK pathway,Wnt/β-catenin pathway,PI3K/AKT/mTOR pathway and so on.TGF-β/Smad is most important one in all the pathways.To understand the relationship between these signaling pathways and the pathogenesis of PCO can provide theoretical basis for clinical prevention of PCO.(Int Rev Ophthalmol,2022,46:123-129)

关 键 词：晶状体上皮细胞 上皮-间质转化 后发性白内障 

分 类 号：R779.66[医药卫生—眼科]