泪腺腺样囊性癌相关的小RNA及其调控作用  

MicroRNA and their regulating effects in lacrimal gland adenoid cystic carcinoma

作　　者：邵雅琪 马建民 Shao Yaqi;Ma Jianmin(BeijingKey Laboratory of Ophthalmology and Visual Science,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,眼科学与视觉科学北京市重点实验室,100730

出　　处：《国际眼科纵览》2022年第2期157-161,共5页International Review of Ophthalmology

基　　金：北京市自然科学基金(7222025);北京市医院管理中心“登峰”人才计划(DFL20190201)。

摘　　要：泪腺腺样囊性癌(lacrimal gland adenoid cystic carcinoma,LGACC)是一种常见的、发生于泪腺的恶性上皮性肿瘤,其复发率和转移率均较高。多种小RNA(miRNA)在LGACC的发生、发展中起重要作用。miR-24-3p过表达可降低LGACC中PRKCH的表达以促进p53/p21表达,从而抑制肿瘤的侵袭。miR-93-5p通过调控Wnt信号通路,靶向下调乳腺癌转移抑制因子1L,而促进LGACC细胞上皮细胞-间充质转化、迁移、侵袭和增生。LGACC中的miR-181a-5p表达上调,也是LGACC细胞增生和迁移的原因之一。(国际眼科纵览,2022,46:157-161)Lacrimal gland adenoid cystic carcinoma(LGACC)is a common malignant epithelial tumor of lacrimal gland,which has high recurrence rate and metastasis rate.In recent years,it has been found that a variety of microRNAs play an important role in the occurrence and development of LGACC.Overexpression of miR-24-3p can promote the expression of p53/p21 by reducing the expression of PRKCH in LGACC,so as to inhibit tumor invasion.MiR-93-5p regulates Wnt signaling pathway and down regulates breast cancer metastasis suppressor 1(BRMS1)L,and promotes epithelial mesenchymal transition(EMT),migration,invasion and proliferation of LGACC cells.The up-regulated expression of miR-181a-5p in LGACC is also one of the reasons for the proliferation and migration of LGACC cells.(Int Rev Ophthalmol,2022,46:157-161)

关 键 词：泪腺腺样囊性癌 小RNA 

分 类 号：R739.7[医药卫生—肿瘤]