再论晶状体悬韧带异常与闭角型青光眼的关系  

Angle-closure glaucoma and lens suspensory ligament:re-evaluation

作　　者：唐莉[1] 王宁利 樊宁[3] 刘旭阳 Tang Li;Wang Ningli;Fan Ning;Liu Xuyang(Department of Ophthalmology,West China Hospital of Sichuan University,Chengdu 610041,China;Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Key Laboratory of Ophthalmology and Visual Science,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China;Shenzhen Eye Hospital,Shenzhen Key Laboratory of Ophthalmology,Jinan University,Shenzhen 518040,China;Xiamen Eye Center,Xiamen University,Xiamen 361011,China)

机构地区：[1]四川大学华西医院眼科,成都610041 [2]首都医科大学附属北京同仁医院北京同仁眼科中心眼科学与视觉科学北京市重点实验室,100730 [3]暨南大学附属深圳眼科医院眼科学深圳市重点实验室,518000 [4]厦门眼科中心厦门大学,361011

出　　处：《眼科》2022年第3期169-174,共6页Ophthalmology in China

基　　金：国家自然科学基金(82070963);成都市科技局技术创新研发项目(2021-YF05-01526-SN);教育部赛尔网络下一代互联网技术创新项目(NGII20190705)。

摘　　要：晶状体位置异常是原发性闭角型青光眼的重要发病机制之一,往往与晶状体悬韧带异常相关。晶状体悬韧带异常主要影响晶状体的厚度、屈光力与位置,进而影响眼前节解剖结构和屈光状态,导致前房深度变化或不稳定。衰老、遗传、外伤、炎症等因素均可影响悬韧带结构与功能。深入研究悬韧带的病理生理有助于理解一些常见的临床现象如合并近视(甚至是高度近视)的闭角型青光眼、闭角型青光眼中的隐匿性晶状体不全脱位、一些闭角型青光眼对缩瞳及虹膜周切治疗的反常反应、年轻的闭角型青光眼往往是全身遗传性疾病的眼部表现等。目前亟需研究与开发简便、精准的术前和术中悬韧带的评估手段和标准。(眼科,2022,31:169-174)The position of the lens plays an important role in the pathogenesis of primary angle-closure disease(PACD).Abnormal of zonular fibers and subsequent lens dislocation can affecting lens size and shape,cause the anterior chamber to become shallow or unstable.Factors such as aging,genetics,trauma and inflammation may affect the structure and function of the zonule and lead to angle-closure glaucoma.Studying the zonule in PACD helps us understand some clinical phenomena such as why myopia is not uncommon in patients with angle-closure;sometimes,the anterior chamber may become shallower and in turn,the aqueous misdirection or malignant glaucoma may occur after using pilocarpine for PACD;younger PACD may often have systemic genetic disease,etc.But at present there is no simple and accurate methods to assess the zonule at preoperation or intraoperation.(Ophthalmol CHN,2022,31:169-174)

关 键 词：晶状体悬韧带 闭角型青光眼 

分 类 号：R775[医药卫生—眼科]