肌层浸润性膀胱癌保留膀胱术后复发的影响因素分析  

Analysis on the Influencing Factors of Recurrence of Muscle-Invasive Bladder Cancer After Bladder-Sparing Surgery

作　　者：林宝东 吴紫扬 黄炎松 林嘉玲 LIN Baodong;WU Ziyang;HUANG Yansong;LIN Jialing(Department of Urology Surgery,Dafeng Hospital of Chaoyang District,Shantou 515154,China)

机构地区：[1]汕头市潮阳区大峰医院泌尿外科,广东汕头515154

出　　处：《临床医学工程》2022年第6期869-870,共2页Clinical Medicine & Engineering

摘　　要：目的 探讨肌层浸润性膀胱癌保留膀胱术后复发的影响因素。方法 回顾性分析90例行肌层浸润性膀胱癌保留膀胱手术患者的临床资料,采用单因素和多因素Logistic回归分析探讨术后复发的影响因素。结果 90例患者中,复发17例,复发率为18.89%。单因素分析显示,肿瘤直径、肿瘤数目、肿瘤分期、肿瘤分级、是否即刻膀胱灌注治疗是术后复发的影响因素(P<0.05)。多因素Logistic回归分析显示,肿瘤直径≥30 mm、肿瘤数目≥8个、高级别尿路上皮癌、肿瘤分期T_(3)-T_(4)是术后复发的独立危险因素,即刻膀胱灌注治疗是保护因素(P<0.05)。结论 肿瘤直径≥30 mm、肿瘤数目≥8个、高级别尿路上皮癌、肿瘤分期T_(3)-T_(4)是肌层浸润性膀胱癌患者保留膀胱术后复发的独立危险因素,而即刻膀胱灌注治疗是保护因素。Objective To explore the influencing factors of recurrence of muscle-invasive bladder cancer after bladder-sparing surgery. Methods The clinical data of 90 patients with muscle-invasive bladder cancer underwent bladder-sparing surgery were retrospectively analyzed. Univariate analysis and multivariate Logistic regression analysis were used to explore the influencing factors of postoperative recurrence. Results Among the 90 patients, 17 cases had recurrence, and the recurrence rate was 18.89%. Univariate analysis showed that tumor diameter, tumor number, tumor stage, tumor grade, and immediate intravesical infusion therapy were the influencing factors for postoperative recurrence(P <0.05). Multivariate Logistic regression analysis showed that tumor diameter ≥30 mm, tumor number≥8, high-grade urothelial carcinoma, and tumor stage T_(3)-T_(4) were independent risk factors for postoperative recurrence, and immediate intravesical infusion therapy was a protective factor(P <0.05). Conclusions Tumor diameter ≥30 mm, tumor number ≥8, high-grade urothelial carcinoma, and tumor stage T_(3)-T_(4) are independent risk factors for recurrence after bladder-sparing surgery in patients with muscle-invasive bladder cancer, and immediate intravesical infusion therapy is a protective factor.

关 键 词：肌层浸润性膀胱癌 保留膀胱手术 复发 影响因素 

分 类 号：R737.14[医药卫生—肿瘤]