A novel aged mouse model of recurrent intracerebral hemorrhage in the bilateral striatum  

作　　者：Li-Min Wang Zhi-Hua Liu Hong-Lei Ren Xue-Mei Chen Jun-Min Wang Hui-Min Cai Li-Ping Wei Hui-Hong Tian Jian Wang Li-Juan Wang 

机构地区：[1]The Second School of Clinical Medicine,Southern Medical University,Guangzhou,Guangdong Province,China [2]Department of Neurology,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangdong Neuroscience Institute,Guangzhou,Guangdong Province,China [3]School of Medicine,South China University of Technology,Guangzhou,Guangdong Province,China [4]Department of Neurology,Tianjin Neurological Institute,Tianjin Medical University General Hospital,Tianjin,China [5]Department of Anatomy,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou,Henan Province,China

出　　处：《Neural Regeneration Research》2023年第2期344-349,共6页中国神经再生研究（英文版）

基　　金：supported by the Natural Science Foundation of Guangdong Province of China,No.2018A030313427;the Science and Technology Program of Guangzhou of China,No.202002030393(both to LMW)。

摘　　要：The current animal models of stroke primarily model a single intracerebral hemorrhage(ICH)attack,and there is a lack of a reliable model of recurrent ICH.In this study,we established 16-month-old C57 B L/6 male mouse models of ICH by injecting collagenaseⅦ-S into the left striatum.Twenty-one days later,we injected collagenaseⅦ-S into the right striatum to simulate recurrent ICH.Our results showed that mice subjected to bilateral striatal hemorrhage had poorer neurological function at the early stage of hemorrhage,delayed recovery in locomotor function,motor coordination,and movement speed,and more obvious emotional and cognitive dysfunction than mice subjected to unilate ral striatal hemorrhage.These findings indicate that mouse models of bilateral striatal hemorrhage can well simulate clinically common recurrent ICH.These models should be used as a novel tool for investigating the pathogenesis and treatment targets of recurrent ICH.

关 键 词：animal model cognition impairment depression-like behavior dopaminergic neurons EMOTION intracerebral hemorrhage motor neurologic function recurrent intracerebral hemorrhage 

分 类 号：R741[医药卫生—神经病学与精神病学]