^(18)F-AlF标记的多肽分子探针在PET肿瘤显像中的研究进展  

Research progress of ^(18)F-AlF-labeled peptide molecular probes in PET tumor imaging

作　　者：韩静雅[1] 陈旸 赵妍 赵新明[1] Han Jingya;Chen Yang;Zhao Yan;Zhao Xinming(Department of Nuclear Medicine,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;Department of Oncology,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China)

机构地区：[1]河北医科大学第四医院核医学科,石家庄050011 [2]河北医科大学第四医院肿瘤内科,石家庄050011

出　　处：《国际放射医学核医学杂志》2022年第3期157-161,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金面上项目(82071959);河北省自然科学基金京津冀基础研究合作专项(H2018206600)。

摘　　要：随着PET在临床中的广泛应用,^(18)F-氟化铝(AlF)标记的多肽分子探针也备受关注。其标记方法简便易行,PET显像的灵敏度及空间分辨率高,可示踪多种生物靶点,从而为肿瘤的精准诊疗提供重要信息,且部分^(18)F-AlF标记的多肽分子探针已进入临床研究阶段,具有良好的应用前景。笔者对^(18)F-AlF标记的多肽生物靶向分子探针在PET肿瘤显像中的研究进展进行综述。With the wide application of PET in clinic,^(18)F-AlF-labeled peptide biomolecular probes are increasing in the spotlight.The procedure of ^(18)F-AlF labeling of biomolecule conjugates is simple,valid and has tremendous potential.^(18)F-AlF-biomolecule conjugates PET imaging has high sensitivity and spatial resolution,with ideal quantification properties to trace biological targets of various tumors,so as to provide important information for accurate diagnosis and treatment of tumors.Part of them are in clinical research stage and show a broad scope in future clinical application.In this paper,the authors review the current process of ^(18)F-AlF-labeled peptide molecular probes for PET tumor imaging.

关 键 词：分子探针 分子影像 氟脱氧葡萄糖F18 正电子发射断层显像术 生物靶点 

分 类 号：R730.44[医药卫生—肿瘤]