非编码RNA在多发性骨髓瘤骨病中调控作用的最新研究进展  

Research Progress of Non-coding RNAs in the Regulation of Multiple Myeloma Bone Disease——Review

作　　者：李素梅 于漫亚 崔兴[2] LI Su-Mei;YU Man-Ya;CUI Xing(College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250011,Shandong Province,China;Department of Hematology,The Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,Shandong Province,China)

机构地区：[1]山东中医药大学中医学院,山东济南250011 [2]山东中医药大学附属医院血液科,山东济南250011

出　　处：《中国实验血液学杂志》2022年第3期950-954,共5页Journal of Experimental Hematology

基　　金：国家自然科学基金面上项目(82074348);泰山学者青年专家人才项目(tsqn201812145);山东省重点研发计划(公益类)(2019GSF108162)。

摘　　要：多发性骨髓瘤骨病是多发性骨髓瘤最常见的并发症,与骨髓瘤的进展相互促进,严重影响患者的生存质量和预后。近年来,许多研究揭示了非编码RNA通过调控基因表达和参与多种信号通路,直接或间接在骨重建失衡中发挥重要作用。另外,由于成骨细胞活性被持续抑制,即使骨髓瘤患者处于完全缓解期,大多数骨损伤也无法愈合,而非编码RNA可作为新的研究方向和临床干预靶点。本文对影响多发性骨髓瘤骨病发生和进展的非编码RNA的最新研究进展作一综述。Multiple myeloma bone disease is the most common complication of multiple myeloma, which mutually promotes the progression of multiple myeloma, severely affects patients′ survival quality and prognosis. Recently,many studies revealed that non-coding RNAs play an important role in the imbalance of bone remodeling by regulating gene expression and participating in various signaling pathways. Additionally, most bone lesions fail to heal even when myeloma patients are in complete remission due to the sustained suppression of osteoblast activity, while non-coding RNAs may become a novel research field and clinical intervention targets. In this review, the latest research advances of non-coding RNAs which affect the occurrence and progress of multiple myeloma bone disease are summarized briefly.

关 键 词：多发性骨髓瘤 骨病 非编码RNA 破骨细胞 成骨细胞 

分 类 号：R733.3[医药卫生—肿瘤]