百可利在帕金森病中的神经保护作用机制研究进展  

Current Advances in Understanding the Mechanism of Neuroprotective Effect of Baicalein in Parkinson's Disease

作　　者：郝丹丹 张垒 郎卫红 王玉敏 HAO Dan-dan;ZHANG Lei;LANG Wei-hong;WANG Yu-min(Department of Physiology,Medical College,Chifeng University,Chifeng 024005,China;Department of Neurosurgery,Affiliated Hospital,Chifeng Medical College,Chifeng University,Chifeng 024005,China;Department of Psychological Medicine,The Affiliated Hospital of Chifeng University,Chifeng 024005,China;Department of Respiratory and Critical Care Medicine,Aerospace Center Hospital,Peking University Aerospace School of Clinical Medicine,Beijing 100049,China)

机构地区：[1]赤峰学院基础医学院生理学教研室,内蒙古赤峰024005 [2]赤峰学院附属医院神经外科,内蒙古赤峰024005 [3]赤峰学院附属医院心理医学科,内蒙古赤峰024005 [4]航天中心医院/北京大学航天临床医学院呼吸与危重医学科,北京100049

出　　处：《中国药学杂志》2022年第7期524-529,共6页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(81260196,81450036);内蒙古自治区高等学校青年科技英才支持计划资助(NJYT-17-B23);内蒙古自治区高校科研项目资助(NJZY19218);内蒙古自然科学基金项目资助(2020MS08175,2021MS08131,2021LHMS08024);内蒙古草原英才计划项目资助;航天医科科研基金资助项目资助(2020YK02,2021YK05)。

摘　　要：百可利(baicalein)是一种重要的黄酮类化合物,主要存在于黄芩的根中。研究表明,百可利在帕金森病的细胞模型和动物模型中具有神经保护作用,其能够抑制α-synuclein蛋白聚集、抗炎作用、调控Nrf2/ARE抗氧化防御体系、抑制铁损伤和抑制脂氧合酶。百可利可作为治疗帕金森病的潜在药物,笔者就百可利在帕金森病中的神经保护作用及其分子机制进行了综述。Baicalein,one of the important flavones,is mainly found in the root of scutellaria baicalensis Georgi.Certain lines of evidence suggest that baicalein has potent neuroprotective effects in vitro and in vivo on Parkinson's disease(PD).Baicalein possesses a range of key pharmacological properties,such as inhibiting aggregation ofα-synuclein(α-syn),anti-inflammatory properties,upregulating antioxidant enzymes,chelating excessive iron,and inhibiting lipoxygenase.The aim of the present study is to summarize the pharmacological neuroprotective actions of baicalein,and provide a comprehensive review of the molecular mechanism by which baicalein exert neuroprotective effect.The current review highlights could be useful to identify novel therapeutic agents in relation to the treatment of PD.

关 键 词：百可利 帕金森病 神经保护 

分 类 号：R741.05[医药卫生—神经病学与精神病学]