剪切波弹性成像E_(max)与乳腺癌CK5/6、p63、AR、EGFR的相关性研究  

Study on the relationship between shear wave elastography E_(max) and CK5/6,p63,AR,EGFR in breast cancer

作　　者：尹郭林 陈武[2] YIN Guolin;CHEN Wu(Department of Medical Imaging,Shanxi Medical University,Shanxi Taiyuan 030001,China;Department of Ultrasonography,the First Hospital of Shanxi Medical University,Shanxi Taiyuan 030001,China)

机构地区：[1]山西医科大学医学影像学院,山西太原030001 [2]山西医科大学第一医院超声科,山西太原030001

出　　处：《现代肿瘤医学》2022年第13期2437-2440,共4页Journal of Modern Oncology

摘　　要：目的:探讨剪切波弹性成像(SWE)定量参数E_(max)与乳腺癌免疫组化指标CK5/6、p63、AR、EGFR的相关性。方法:术前对166例乳腺癌结节行常规超声和SWE检查。常规超声获取病灶最大径,SWE检查测量病灶最大弹性值E_(max)。以术后病理结果为金标准,记录病灶组织学分级、有无淋巴结转移以及免疫组化标志物CK5/6、p63、AR和EGFR。单因素分析采用Spearman秩相关,将单因素分析有统计学差异的变量纳入多元线性回归。结果:单因素分析结果显示,E_(max)与病灶大小、组织学分级、有无淋巴结转移中的差异有统计学意义(P<0.05),E_(max)在p63、AR阳性表达组与阴性表达组间有统计学差异(P<0.05)。多元线性回归分析结果显示,仅病灶大小与Emax呈显著相关(P<0.05)。结论:SWE定量参数E_(max)与乳腺癌病灶大小、组织学分级、腋窝淋巴结转移及p63、AR和EGFR的表达有关。术前SWE检查可能成为预测乳腺癌患者预后的一种新技术手段。Objective:To investigate the correlation between the quantitative parameter E_(max)of shear wave elastography(SWE)and the immunohistochemical indexes of breast cancer,such as CK5/6,p63,AR and EGFR.Methods:Conventional ultrasound and SWE examination were performed in 166 cases of breast cancer nodules before operation.The maximum diameter of the lesion was obtained by conventional ultrasound,and the maximum elastic value E_(max)was measured by SWE.According to the postoperative pathological results as the gold standard,the histological grade of the lesion,lymph node metastasis and immunohistochemical markers CK5/6,p63,AR and EGFR were recorded.Spearman rank correlation was used in univariate analysis,and the variables with statistical differences in univariate analysis were included in multiple linear regression.Results:Univariate analysis showed that there were significant differences between E_(max)and lesion size,histological grade and lymph node metastasis(P<0.05).There was significant difference in),E_(max)between p63 and AR positive expression group and negative expression group(P<0.05).Multiple linear regression analysis showed that only the lesion size was significantly correlated with E_(max).Conclusion:The quantitative parameter E_(max)of SWE was related to tumor size,histological grade,axillary lymph node metastasis and the expression of p63,AR and EGFR.Preoperative SWE examination may be a new technical method to predict the prognosis of patients with breast cancer.

关 键 词：剪切波弹性成像 最大弹性值 免疫组化 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]